Primary Information |
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| BoMiProt ID | Bomi364 |
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| Protein Name | Serine/threonine-protein kinase 10 |
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| Organism | Bos taurus |
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| Uniprot ID | E1BK52 |
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| Milk Fraction | Exosome |
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| Aminoacid Length | 966 |
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| Molecular Weight | 111615 |
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| FASTA Sequence |
Download |
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| Gene Name | STK10 |
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| Protein Existence Status | Reviewed: Protein inferred from homology |
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Secondary Information |
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| Protein Function | Interact with
diverse substrates ranging from enzymes, including other
kinases, to transcription factors, receptors, and other regulatory proteins |
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| Significance in milk | Increase in protein supports milk protein synthesis during the periparturient period |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | 315-381,417-488,863-871,960-966 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1. Ma, Y. F. et al. (2019) ‘Phosphorylation of AKT serine/threonine kinase and abundance of milk protein synthesis gene networks in mammary tissue in response to supply of methionine in periparturient Holstein cows’, Journal of Dairy Science, 102(5), pp. 4264–4274. doi: 10.3168/jds.2018-15451.
2. Nerstedt, A. et al. (2012) ‘Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle’, Diabetologia, 55(6), pp. 1797–1807. doi: 10.1007/s00125-012-2511-7.
3. Kostich, M. et al. (2002) ‘Human members of the eukaryotic protein kinase family.’, Genome Biology, 3(9), p. research0043.1. doi: 10.1186/gb-2002-3-9-research0043. |
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