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Primary Information | |
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| BoMiProt ID | Bomi3627 |
| Protein Name | Actin-related protein 2/3 complex subunit 5/Arp2/3 complex 16 kDa subunit/p16-ARC |
| Organism | Bos taurus |
| Uniprot ID | Q3SYX9 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_001030524.1 |
| Aminoacid Length | 151 |
| Molecular Weight | 16230 |
| FASTA Sequence | Download |
| Gene Name | ARPC5 |
| Gene ID | 614345 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | Component of the Arp2/3 complex, Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. |
| Biochemical Properties | Arp2/3 (actin-related protein 2/3) complex is a seven-subunit complex that nucleates branched actin filaments in response to cellular signals. Nucleation-promoting factors such as WASp/Scar family proteins activate the complex by facilitating the activating conformational change and recruiting the first actin monomer for the daughter branch. |
| PTMs | Acetylation, Ubl conjugation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | na |
| SCOP | Class : All alpha proteins Fold : alpha-alpha superhelix Superfamily : Arp2/3 complex 16 kDa subunit ARPC5 Family : Arp2/3 complex 16 kDa subunit ARPC5 Domain Name : 1K8K G:9-151 |
| CATH | Matched CATH superfamily 1.25.40.190 |
| Predicted Disorder Regions | (1-75) |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| Significance of PTMs | Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation. |
| PDB ID | 1K8K,1TYQ,1U2V,2P9I,2P9K,2P9L,2P9N,2P9P,2P9S,2P9U,3DXK,3DXM,3RSE,3UKR,3UKU,3ULE,4JD2,4XEI,4XF2,6DEC, |