Primary Information |
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| BoMiProt ID | Bomi3609 |
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| Protein Name | Acetylcholine receptor subunit epsilon |
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| Organism | Bos taurus |
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| Uniprot ID | P02715 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776697.1 |
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| Aminoacid Length | 491 |
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| Molecular Weight | 54565 |
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| FASTA Sequence |
Download |
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| Gene Name | CHRNE |
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| Gene ID | 281688 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Subunit of Ach Receptor.AChR is a pentamer consisting of α, β, γ, δ, and ε protein subunits.Imp role in neuromuscular transmission. |
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| PTMs | Disulfide bond, Glycosylation,Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P02715|ACHE_BOVIN Acetylcholine receptor subunit epsilon OS=Bos taurus OX=9913 GN=CHRNE PE=2 SV=1
MAGALLCALLLLQLLGRGEGKNEELRLYHYLFDTYDPGRRPVQEPEDTVTISLKVTLTNL
ISLNEKEETLTTSVWIGIDWQDYRLN*86YSKGDFGGVETLRVPSELVWLPEIVLENNIDGQF
GVAYEANVLVSEGGYLSWLPPAIYRSTCAVEVTYFPFDWQN*161CSLVFRSQTYNAEEVEFVF
AVDDEGKTISKIDIDTEAYTENGEWAIDFCPGVIRRHDGDSAGGPGETDVIYSLIIRRKP
LFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKTPETSLS
VPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTTHAMSPRLRYVLLELLPQLLGSGAPP
EIPRAASPPRRASSLGLLLRAEELILKKPRSELVFEQQRHRHGTWTATLCQNLGAAAPEI
RCCVDAVNFVASSTRDQEATGEEVSDWVRMGKALDSICFWAALVLFLVGSSLIFLGAYFN
RVPQLPYPPCM
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 4TMHs; (241-263),(274-292),(307-329) and (457-479) |
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| Significance of PTMs | Phosphorylation on epsilon subunit by caMP pathway which is imp for AchR stabilization.Electrical activity tends to increase pkA dependent phosphorylation of epsilon subunit. |
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| Additional Comments | ACh is a neurotransmitter involved in sympathetic, parasympathetic, and motor nerves. Additionally, the ACh synthesized/released by non-neuronal cells and tissues (collectively known as non-neuronal ACh) has been reported to be responsible for local intercellular signaling |
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| Bibliography | 1.Makino Y, Hiradate Y, Umezu K, Hara K, Tanemura K. Expression and Possible Role of Nicotinic Acetylcholine Receptor ε Subunit (AChRe) in Mouse Sperm. Biology (Basel). 2021 Jan 11;10(1):46. doi: 10.3390/biology10010046. PMID: 33440720; PMCID: PMC7826850. 2.Lanuza MA, Gizaw R, Viloria A, González CM, Besalduch N, Dunlap V, Tomàs J, Nelson PG. Phosphorylation of the nicotinic acetylcholine receptor in myotube-cholinergic neuron cocultures. J Neurosci Res. 2006 Jun;83(8):1407-14. doi: 10.1002/jnr.20848. PMID: 16555299. |
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