Primary Information
BoMiProt ID	Bomi3571
Protein Name	6-phosphogluconolactonase
Organism	Bos taurus
Uniprot ID	Q2TBQ8
Milk Fraction	Exosomes
Ref Sequence ID	NP_001033669.1
Aminoacid Length	258
Molecular Weight	27547
FASTA Sequence	Download
Gene Name	PGLS
Gene ID	616120
Protein Existence Status	Reviewed
Secondary Information
Protein Function	6-phosphogluconolactonase (PGLS), a cytosolic enzyme in the oxidative phase of the pentose phosphate pathway (PPP), expressing cells are associated with undifferentiated HCC subtypes.
PTMs	Phosphorylation at Serine,N-acetylation at Alanine
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q2TBQ8|6PGL_BOVIN 6-phosphogluconolactonase OS=Bos taurus OX=9913 GN=PGLS PE=2 SV=1 MAAPAPRLISVFSSPQELGASLAQLVVQQAACCLADAGARFTLGLSGGS*49LVSMLARELPA AAAPAGPASLARWTLGFCDERLVPFEHAESTYGLYRTHLLSKLPIFDSQVITINPALPVE EAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQEREKIVAPISDSPK PPPQRVTLTLPVLNAARTVIYVATGEGKAAILKRILEDKEENPLPAALVQPSAGKLCWFL DEAAARLLTVPFEKHSTL
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.Li C, Chen J, Li Y, Wu B, Ye Z, Tian X, Wei Y, Hao Z, Pan Y, Zhou H, Yang K, Fu Z, Xu J, Lu Y. 6-Phosphogluconolactonase Promotes Hepatocellular Carcinogenesis by Activating Pentose Phosphate Pathway. Front Cell Dev Biol. 2021 Oct 26;9:753196. doi: 10.3389/fcell.2021.753196. PMID: 34765603; PMCID: PMC8576403. 2.