Search by BoMiProt ID - Bomi3564


Primary Information

BoMiProt ID Bomi3564
Protein Name 60S ribosomal protein L5
Organism Bos taurus
Uniprot IDQ58DW5
Milk FractionWhey
Ref Sequence ID NP_001030383.1
Aminoacid Length 297
Molecular Weight 34345
FASTA Sequence Download
Gene Name RPL5
Gene ID 515238
Protein Existence Status reviewed

Secondary Information

Protein Function Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. RPL5 represents a preferred target during human tumorigenesis in cancers with wild-type p53.
Biochemical Properties Ribosomal protein L5 forms a small, extraribosomal complex with 5 S ribosomal RNA, referred to as the 5 S ribonucleoprotein complex, which shuttles between nucleus and cytoplasm in Xenopus oocytes.
PTMs Acetylation,Phosphorylation,Ubl conjugation,Isopeptide bond formation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q58DW5|RL5_BOVIN 60S ribosomal protein L5 OS=Bos taurus OX=9913 GN=RPL5 PE=2 SV=3 MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDI ICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYE GQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRF PGYDS*185ESKEFSAEVHRKHIMGQNVADYMRYLIEEDEDAYKKQFSQYIKNNVT*232PDMMEEMY KKAHAAIRENPVYEKKPKKEVKKKRWNRPKMS*272LAQKKDRVAQKKASFLRAQERAAES
Predicted Disorder Regions 1-46, 248-297
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments RPL5 mutations may impair wild-type p53 upregulation and ribosome biogenesis.
Bibliography 1.Oršolić I, Bursać S, Jurada D, Drmić Hofman I, Dembić Z, Bartek J, Mihalek I, Volarević S. Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint. Oncogene. 2020 Apr;39(17):3443-3457. doi: 10.1038/s41388-020-1231-6. Epub 2020 Feb 27. PMID: 32108164. 2.Claussen M, Rudt F, Pieler T. Functional modules in ribosomal protein L5 for ribonucleoprotein complex formation and nucleocytoplasmic transport. J Biol Chem. 1999 Nov 26;274(48):33951-8. doi: 10.1074/jbc.274.48.33951. PMID: 10567357.