Primary Information |
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| BoMiProt ID | Bomi3552 |
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| Protein Name | 60S ribosomal protein L23a |
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| Organism | Bos taurus |
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| Uniprot ID | Q24JY1 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_001039423.1 |
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| Aminoacid Length | 156 |
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| Molecular Weight | 17695 |
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| FASTA Sequence |
Download |
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| Gene Name | RPL23A |
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| Gene ID | 507168 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | testis |
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| Protein Function | PDRL23A is found to interact with 60 S ribosomal protein L26 (RPL26), hampering RPL26-governed p53 translation, and resulting in a reduction in the level of p53 protein, which in turn reduced p53-mediated apoptosis under hypoxic conditions. |
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| PTMs | N6-Acetylation at Lys,Citrullination,Isopeptide bond formation, N,N,N-trimethylation at Ala, Phosphorylation at Ser, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q24JY1|RL23A_BOVIN 60S ribosomal protein L23a OS=Bos taurus OX=9913 GN=RPL23A PE=2 SV=1
MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTS*43PT*45FRRPKTLRLRRQPKY
PRKSAPRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDID
VAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII
|
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| Predicted Disorder Regions | (1-70) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Yin A, Feng M, Zhang L, Cheng Z, Li Y, Qian L. Identification of a novel native peptide derived from 60S ribosomal protein L23a that translationally regulates p53 to reduce myocardial ischemia-reperfusion. Pharmacol Res. 2022 Jan;175:105988. doi: 10.1016/j.phrs.2021.105988. Epub 2021 Nov 19. PMID: 34808368. 2. |
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