Primary Information |
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| BoMiProt ID | Bomi3549 |
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| Protein Name | 60S ribosomal protein L18 |
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| Organism | Bos taurus |
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| Uniprot ID | Q5E973 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001015556.1 |
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| Aminoacid Length | 188 |
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| Molecular Weight | 21535 |
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| FASTA Sequence |
Download |
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| Gene Name | RPL18 |
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| Gene ID | 509163 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Component of the large ribosomal subunit.L18 inhibited both PKR autophosphorylation and PKR-mediated phosphorylation of eIF-2alpha thus prevents polypeptide chain initiation. In such a manner, activated PKR inhibits cell growth and induces apoptosis. |
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| Biochemical Properties | RNA binding activity. L18 is a 22-kDa protein |
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| PTMs | Removal of Methionine,phosphorylation on Ser and Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q5E973|RL18_BOVIN 60S ribosomal protein L18 OS=Bos taurus OX=9913 GN=RPL18 PE=2 SV=3
MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPP
LSLSRMIRKMKLPGREGKTAVVVGTITDDVRVQEVPKLKVCALRVSSRARSRILKAGGKI
LTFDQLALDS*130PKGCGTVLLSGPRKGREVYRHFGKAPGT*158PHSHTKPYVRSKGRKFERARGR
RASRGYKN
|
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| Predicted Disorder Regions | 1-28, 63-78, 100-113, 150-188 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | In E coli L18,removal of Methionine from N terminal by methionine aminopeptidase (MAP).The 2nd residue following Met is Asp. |
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| Bibliography | 1.Nesterchuk MV, Sergiev PV, Dontsova OA. Posttranslational Modifications of Ribosomal Proteins in Escherichia coli. Acta Naturae. 2011 Apr;3(2):22-33. PMID: 22649682; PMCID: PMC3347575. 2.Kumar KU, Srivastava SP, Kaufman RJ. Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18. Mol Cell Biol. 1999 Feb;19(2):1116-25. doi: 10.1128/MCB.19.2.1116. PMID: 9891046; PMCID: PMC116041. |
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