|Protein Name||Secretoglobin family 1D member|
|Milk Fraction||Whey, MFGM|
|Ref Sequence ID||NP_001071275.1|
|Protein Existence Status||Reviewed: Protein inferred from homology|
|Presence in other biological fluids/tissue/cells||breast carcinomas, estrogen receptor positive tumors; abundantly expressed in normal and malignant tissue from the breast, cervix, uterus, ovary, kidney and prostate; Lower or rare lipophilin B expression was found in normal colon, pancreas, heart, in gastric and rectal tumors, and as previously reported in normal testis and placenta and lung tumors; lipophilin B expression was also detected in the normal anterior pituitary and pituitary adenomas, in normal adrenal gland, cartilage, retina, skin, and salivary gland|
|Protein Function||Secretoglobins are small, secreted proteins increasingly recognized for their prognostic capacity in a variety of human cancers, though the precise pathophysiologic functions for most members remain to be elucidated|
|Biochemical Properties||Also known as lipophilin B; small and secretory; dimeric proteins; in breast cancer mammaglobin A and lipophilin B proteins form a covalent complex, and that the two proteins are bonded in a head-to-tail orientation; lipophilin binds PS, PA, or PG preferentially over PC|
|Significance in milk||More in colustrum; role in lipid droplet transport and nutrient delivery|
| Site(s) of PTM(s) |
|Predicted Disorder Regions||NA|
|TM Helix Prediction||1TMH; (7-29)|
|Bibliography||1. Boggs, J. M. et al. (1977) ‘Lipid phase separation induced by a hydrophobic protein in phosphatidylserine-phosphatidylcholine vesicles’, Biochemistry, 16(11), pp. 2325–2329. doi: 10.1021/bi00630a003. |
2. Ni, J. et al. (2000) ‘All human genes of the uteroglobin family are localized on chromosome 11q12.2 and form a dense cluster.’, Annals of the New York Academy of Sciences, 923(1), pp. 25–42. doi: 10.1111/j.1749-6632.2000.tb05517.x.
3. Sjödin, A. et al. (2003) ‘Dysregulated secretoglobin expression in human lung cancers.’, Lung cancer (Amsterdam, Netherlands), 41(1), pp. 49–56. doi: 10.1016/s0169-5002(03)00126-0.
4. O’Brien, N. et al. (2002) ‘Mammaglobin a: a promising marker for breast cancer.’, Clinical chemistry, 48(8), pp. 1362–4. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12142396 (Accessed: 3 October 2019).
5. Carter, D. et al. (2003) ‘Serum antibodies to lipophilin B detected in late stage breast cancer patients.’, Clinical cancer research : an official journal of the American Association for Cancer Research, 9(2), pp. 749–54. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12576445 (Accessed: 3 October 2019).
6. Colpitts, T. L. et al. (2001) ‘Mammaglobin Is Found in Breast Tissue as a Complex with BU101’, Biochemistry, 40(37), pp. 11048–11059. doi: 10.1021/bi010284f.
7. Zafrakas, M. et al. (2006) ‘Expression analysis of mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2) in more than 300 human tumors and matching normal tissues reveals their co-expression in gynecologic malignancies’, BMC Cancer, 6(1), p. 88. doi: 10.1186/1471-2407-6-88.