Primary Information |
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BoMiProt ID | Bomi3529 |
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Protein Name | 4-hydroxybenzoate polyprenyltransferase, mitochondrial/4-HB polyprenyltransferase/Para-hydroxybenzoate--polyprenyltransferase/PHB:polyprenyltransferase/PHB:PPT |
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Organism | Bos taurus |
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Uniprot ID | Q2KIQ4 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001039358.1 |
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Aminoacid Length | 371 |
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Molecular Weight | 40628 |
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FASTA Sequence |
Download |
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Gene Name | COQ2 |
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Gene ID | 504633 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | role in coenzyme Q (CoQ) biosynthesis. |
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Biochemical Properties | This enzyme catalyzes the second step of the final reaction sequence of CoQ biosynthesis, the condensation of 4-hydroxybenzoate with polyprenyl-pyrophosphate, generating the first membrane-bound CoQ intermediate.Requires Mg2+ as a cofactor. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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Predicted Disorder Regions | 1-6, 18-63, 361-371 |
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DisProt Annotation | |
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TM Helix Prediction | 7TMHs; (109-127), (160-182), (201-223),(230-252),(278-296),(303-321),(333-355) |
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Bibliography | Desbats MA, Morbidoni V, Silic-Benussi M, Doimo M, Ciminale V, Cassina M, Sacconi S, Hirano M, Basso G, Pierrel F, Navas P, Salviati L, Trevisson E. The COQ2 genotype predicts the severity of coenzyme Q10 deficiency. Hum Mol Genet. 2016 Oct 1;25(19):4256-4265. doi: 10.1093/hmg/ddw257. Epub 2016 Aug 4. PMID: 27493029. |