Search by BoMiProt ID - Bomi3529

Primary Information

BoMiProt ID Bomi3529
Protein Name 4-hydroxybenzoate polyprenyltransferase, mitochondrial/4-HB polyprenyltransferase/Para-hydroxybenzoate--polyprenyltransferase/PHB:polyprenyltransferase/PHB:PPT
Organism Bos taurus
Uniprot IDQ2KIQ4
Milk FractionWhey
Ref Sequence ID NP_001039358.1
Aminoacid Length 371
Molecular Weight 40628
FASTA Sequence Download
Gene Name COQ2
Gene ID 504633
Protein Existence Status reviewed

Secondary Information

Protein Function role in coenzyme Q (CoQ) biosynthesis.
Biochemical Properties This enzyme catalyzes the second step of the final reaction sequence of CoQ biosynthesis, the condensation of 4-hydroxybenzoate with polyprenyl-pyrophosphate, generating the first membrane-bound CoQ intermediate.Requires Mg2+ as a cofactor.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-6, 18-63, 361-371
DisProt Annotation
TM Helix Prediction 7TMHs; (109-127), (160-182), (201-223),(230-252),(278-296),(303-321),(333-355)
Bibliography Desbats MA, Morbidoni V, Silic-Benussi M, Doimo M, Ciminale V, Cassina M, Sacconi S, Hirano M, Basso G, Pierrel F, Navas P, Salviati L, Trevisson E. The COQ2 genotype predicts the severity of coenzyme Q10 deficiency. Hum Mol Genet. 2016 Oct 1;25(19):4256-4265. doi: 10.1093/hmg/ddw257. Epub 2016 Aug 4. PMID: 27493029.