Search by BoMiProt ID - Bomi3508

Primary Information

BoMiProt ID Bomi3508
Protein Name 40S ribosomal protein S12
Organism Bos taurus
Uniprot IDQ76I81
Milk FractionWhey,MFGM
Ref Sequence ID NP_001014409.1
Aminoacid Length 132
Molecular Weight 14515
FASTA Sequence Download
Gene Name RPS12
Gene ID 326582
Protein Existence Status Reviewed

Secondary Information

Protein Function Component of Ribosome.Essential for ribosome assembly.RPS12 overexpression increases heavy polysome association of APAF-1 and XIAP mRNAs.RPS12 overexpression in monosomes minimally influenced the polysome distribution of these mRNAs in normoxia, suggesting a requirement for other hypoxia-induced pathways.
Biochemical Properties RPS12 is located on the outer surface in the beak of the ribosome, near the mRNA entry channel and where translation initiation factors eIF3 and DHX29 bind to cooperate in scanning of structured mRNAs.
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Brumwell, A., Fell, L., Obress, L., & Uniacke, J. (2020). Hypoxia influences polysome distribution of human ribosomal protein S12 and alternative splicing of ribosomal protein mRNAs. Rna, 26(3), 361-371.