Primary Information |
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| BoMiProt ID | Bomi3508 |
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| Protein Name | 40S ribosomal protein S12 |
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| Organism | Bos taurus |
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| Uniprot ID | Q76I81 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001014409.1 |
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| Aminoacid Length | 132 |
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| Molecular Weight | 14515 |
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| FASTA Sequence |
Download |
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| Gene Name | RPS12 |
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| Gene ID | 326582 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | Component of Ribosome.Essential for ribosome assembly.RPS12 overexpression increases heavy polysome association of APAF-1 and XIAP mRNAs.RPS12 overexpression in monosomes minimally influenced the polysome distribution of these mRNAs in normoxia, suggesting a requirement for other hypoxia-induced pathways. |
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| Biochemical Properties | RPS12 is located on the outer surface in the beak of the ribosome, near the mRNA entry channel and where translation initiation factors eIF3 and DHX29 bind to cooperate in scanning of structured mRNAs. |
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| PTMs | Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Brumwell, A., Fell, L., Obress, L., & Uniacke, J. (2020). Hypoxia influences polysome distribution of human ribosomal protein S12 and alternative splicing of ribosomal protein mRNAs. Rna, 26(3), 361-371. |
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