Primary Information |
|---|
| BoMiProt ID | Bomi3499 |
|---|
| Protein Name | 3-hydroxyisobutyrate dehydrogenase, mitochondrial |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | Q2HJD7 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001039571.1 |
|---|
| Aminoacid Length | 336 |
|---|
| Molecular Weight | 35410 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | HIBADH |
|---|
| Gene ID | 512002 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Presence in other biological fluids/tissue/cells | HIBADH is primarily expressed in the mitochondria of the liver, kidney, muscle, and cultured neuron cells |
|---|
| Protein Function | sperm-motility marker. Participates in L-valine degradation pathway, which is part of Amino-acid degradation. |
|---|
| Biochemical Properties | Tetrameric mitochondrial enzyme.Belongs to oxidoreductases,acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.Catalyses the following reaction-3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + H+ + NADH |
|---|
| PTMs | Acetylation |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
|---|
| Predicted Disorder Regions | NA |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Additional Comments | methylation in the 5'-flanking region could affect the bovine sperm motility through the regulation of HIBADH gene transcriptional activity. |
|---|
| Bibliography | Zhang S, Zhang Y, Yang C, Ju Z, Wang X, Jiang Q, Sun Y, Huang J, Zhong J, Wang C. The g.-165 T>C Rather than Methylation Is Associated with Semen Motility in Chinese Holstein Bulls by Regulating the Transcriptional Activity of the HIBADH Gene. PLoS One. 2015 Jul 2;10(7):e0127670. doi: 10.1371/journal.pone.0127670. PMID: 26133183; PMCID: PMC4489673. |
|---|
