Primary Information
BoMiProt ID	Bomi3498
Protein Name	3-hydroxyacyl-CoA dehydrogenase type-2/17-beta-estradiol 17-dehydrogenase/3-hydroxy-2-methylbutyryl-CoA dehydrogenase /Endoplasmic reticulum-associated amyloid beta-peptide-binding protein/Short chain dehydrogenase/reductase family 5C member 1
Organism	Bos taurus
Uniprot ID	O02691
Milk Fraction	Whey
Ref Sequence ID	NP_776759.1
Aminoacid Length	261
Molecular Weight	27140
FASTA Sequence	Download
Gene Name	HSD17B10
Gene ID	281809
Protein Existence Status	Reviewed
Secondary Information
Presence in other biological fluids/tissue/cells	liver
Protein Function	The short-chain l-3-hydroxyacyl-CoA dehydrogenase (SCHAD) protein is involved in the penultimate step of mitochondrial fatty acid oxidation. common variants in HADHSC on chromosome 4q22-26 might be associated with development of type 2 diabetes.
Biochemical Properties	The catalytic entity reveals an alpha/beta short chain alcohol dehydrogenase/reductase (SDR) fold and the conformation of the bound nicotinamide adenine dinucleotide (NAD(+)) found in other SDR enzymes.
PTMs	N-acetylation at Ala
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.van Hove EC, Hansen T, Dekker JM, Reiling E, Nijpels G, Jørgensen T, Borch-Johnsen K, Hamid YH, Heine RJ, Pedersen O, Maassen JA, 't Hart LM. The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study. Diabetes. 2006 Nov;55(11):3193-6. doi: 10.2337/db06-0414. PMID: 17065362.