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Primary Information | |
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| BoMiProt ID | Bomi3493 |
| Protein Name | 39S ribosomal protein L22, mitochondrial |
| Organism | Bos taurus |
| Uniprot ID | Q3SZX5 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_001030531.1 |
| Aminoacid Length | 204 |
| Molecular Weight | 23552 |
| FASTA Sequence | Download |
| Gene Name | MRPL22/L22mt |
| Gene ID | 614639 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | ribosome assembly |
| Biochemical Properties | PI value of phosphorylated Bovine Mitochondrial Ribosomal Protein is 9.87.Size.Mol wt is 24.2kDa.A deletion of Met82-Lys83-Arg84 in bacterial L22 leads to erythromycin resistance inhibiting peptide chain elongation.Several Ser, Thr, and Tyr residues are clustered in close proximity to the conserved Lys83-Arg84 in bacteria resulting in erythromycin resistance. |
| PTMs | Ubl conjugation at Lys191 |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | na |
| SCOP | Class : Alpha and beta proteins (a/b) Fold : 50S Ribosomal protein L22 Superfamily : Ribosomal protein L22 Family : Ribosomal protein L22 Domain Name : 2FTC M:1-110 |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | no TM helices |
| PDB ID | 2FTC,3IY9, |
| Bibliography | 1.Miller, J. L., Cimen, H., Koc, H., & Koc, E. C. (2009). Phosphorylated proteins of the mammalian mitochondrial ribosome: implications in protein synthesis. Journal of proteome research, 8(10), 4789–4798. https://doi.org/10.1021/pr9004844 2.Suzuki, T., Terasaki, M., Takemoto-Hori, C., Hanada, T., Ueda, T., Wada, A., & Watanabe, K. (2001). Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. The Journal of biological chemistry, 276(24), 21724–21736. https://doi.org/10.1074/jbc.M100432200 |