Primary Information |
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| BoMiProt ID | Bomi349 |
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| Protein Name | Sodium- and chloride-dependent creatine transporter 1 |
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| Organism | Bos taurus |
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| Uniprot ID | O18875 |
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| Milk Fraction | MFGM, Exosome |
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| Ref Sequence ID | NP_777036.1 |
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| Aminoacid Length | 635 |
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| Molecular Weight | 70676 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC6A8 |
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| Gene ID | 282367 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | abundant in tissues with high energy demands, e.g. skeletal
muscle, heart, brain and retina and also absorptive functions
such as the kidney and intestine; high in the olfactory bulb, granule
cells of the dentate gyrus of the hippocampus, pyramidal
neurons of the cerebral cortex, Purkinje cells of the cerebellum,
motor and sensory cranial nerve nuclei in the brainstem
and the dorsal and ventral horns of the spinal cord |
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| Protein Function | Creatine uptake by neurons requires a specific creatine
transporter |
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| Biochemical Properties | Rat neuronal
CRT exhibited a very strong Na+-dependence and in
common with the known properties of creatine transporters; creatine uptake was effectively inhibited by
known competitive inhibitors of the CRT (GPA, GBA,
cycloCr and GA) |
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| Significance in milk | nutrient transport systems for milk precursors and constituents |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | (1-44) |
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| DisProt Annotation | |
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| TM Helix Prediction | 12TMHs; (61-79),(91-113),(133-155),(229-251),(269-291),(306-328),(341-363),(393-415),(445-463),(482-500),(522-540),(559-581) |
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| Bibliography | 1. Dodd, J. R. et al. (2010) ‘Functional and immunocytochemical characterization of the creatine transporter in rat hippocampal neurons’, Journal of Neurochemistry, 115(3), pp. 684–693. doi: 10.1111/j.1471-4159.2010.06957.x.
2. Mak, A. K. Y. et al. (2009) ‘Gray matter reduction associated with emotion regulation in female outpatients with major depressive disorder: A voxel-based morphometry study’, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(7), pp. 1184–1190. doi: 10.1016/j.pnpbp.2009.06.025. |
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