Search by BoMiProt ID - Bomi349

Primary Information

BoMiProt ID Bomi349
Protein Name Sodium- and chloride-dependent creatine transporter 1
Organism Bos taurus
Uniprot IDO18875
Milk FractionMFGM, Exosome
Ref Sequence ID NP_777036.1
Aminoacid Length 635
Molecular Weight 70676
FASTA Sequence Download
Gene Name SLC6A8
Gene ID 282367
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells abundant in tissues with high energy demands, e.g. skeletal muscle, heart, brain and retina and also absorptive functions such as the kidney and intestine; high in the olfactory bulb, granule cells of the dentate gyrus of the hippocampus, pyramidal neurons of the cerebral cortex, Purkinje cells of the cerebellum, motor and sensory cranial nerve nuclei in the brainstem and the dorsal and ventral horns of the spinal cord
Protein Function Creatine uptake by neurons requires a specific creatine transporter
Biochemical Properties Rat neuronal CRT exhibited a very strong Na+-dependence and in common with the known properties of creatine transporters; creatine uptake was effectively inhibited by known competitive inhibitors of the CRT (GPA, GBA, cycloCr and GA)
Significance in milk nutrient transport systems for milk precursors and constituents
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions (1-44)
DisProt Annotation
TM Helix Prediction 12TMHs; (61-79),(91-113),(133-155),(229-251),(269-291),(306-328),(341-363),(393-415),(445-463),(482-500),(522-540),(559-581)
Bibliography 1. Dodd, J. R. et al. (2010) ‘Functional and immunocytochemical characterization of the creatine transporter in rat hippocampal neurons’, Journal of Neurochemistry, 115(3), pp. 684–693. doi: 10.1111/j.1471-4159.2010.06957.x.
2. Mak, A. K. Y. et al. (2009) ‘Gray matter reduction associated with emotion regulation in female outpatients with major depressive disorder: A voxel-based morphometry study’, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(7), pp. 1184–1190. doi: 10.1016/j.pnpbp.2009.06.025.