Primary Information |
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| BoMiProt ID | Bomi3460 |
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| Protein Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4/PLC-85/Phosphoinositide phospholipase C-delta-4/Phospholipase C-delta-2/Phospholipase C-delta-4 |
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| Organism | Bos taurus |
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| Uniprot ID | P21671 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001039954.1 |
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| Aminoacid Length | 791 |
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| Molecular Weight | 90581 |
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| FASTA Sequence |
Download |
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| Gene Name | PLCD4/PLCD2 |
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| Gene ID | 540771 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | PLC delta 4 is expressed in nucleus in response to mitogenic stimulation and plays important roles in cell growth as one of the early genes expressed during the transition from G1- to S-phase in the cell cycle.PLC delta 4 mRNA is expressed more remarkably in regenerating liver than in normal resting liver.Acrosome reaction in sperm. |
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| Biochemical Properties | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores.PLC isozymes contain catalytic X and Y domains as well as various regulatory domains, including the C2 domain,EF-Hand domain and pleckstrin homology domain(PH). |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 444-478 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Additional Comments | To date, four PLCδ isozymes have been reported. It has been suggested that PLCδ1 is involved in Alzheimer’s disease and is essential for hypertension. |
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| Bibliography | 1.Liu N, Fukami K, Yu H, Takenawa T. A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus. J Biol Chem. 1996 Jan 5;271(1):355-60. doi: 10.1074/jbc.271.1.355. PMID: 8550586. 2.Irino Y, Cho H, Nakamura Y, Nakahara M, Furutani M, Suh PG, Takenawa T, Fukami K. Phospholipase C delta-type consists of three isozymes: bovine PLCdelta2 is a homologue of human/mouse PLCdelta4. Biochem Biophys Res Commun. 2004 Jul 23;320(2):537-43. doi: 10.1016/j.bbrc.2004.05.206. PMID: 15219862. |
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