Primary Information |
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| BoMiProt ID | Bomi345 |
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| Protein Name | SAM domain and HD domain-containing protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q0VCA5 |
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| Milk Fraction | MFGM |
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| Ref Sequence ID | NP_001069329.1 |
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| Aminoacid Length | 589 |
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| Molecular Weight | 68239 |
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| FASTA Sequence |
Download |
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| Gene Name | SAMHD1 |
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| Gene ID | 524683 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Protein Function | dNTP
phosphohydrolase restricts viral replication by limiting
the cellular dNTP pool; Mg2+-dependent homotetrameric enzyme indiscriminately hydrolyzes all dNTPs to deoxynucleoside and tripolyphosphate products; plays a key role in an innate immunity pathway that restricts HIV-1 infection of resting immune cells by preventing efficient completion of reverse transcription |
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| Biochemical Properties | Two isoforms of mSAMHD1 resulting from alternative splicing
share about 72–74% sequence identities with hSAMHD1; allosterically activated by
nucleotides |
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| Significance in milk | involved in defense, immune and inflammatory reactions |
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| PTMs | Phosphoryalted: isoform 1 (iso1) has a phosphorylation site at residue
T634 |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | (1-41) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | regulates its antiviral activity |
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| Bibliography | 1. Seamon, K. J. et al. (2015) ‘SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity’, Nucleic Acids Research, 43(13), pp. 6486–6499. doi: 10.1093/nar/gkv633.
2. Buzovetsky, O. et al. (2018) ‘The SAM domain of mouse SAMHD1 is critical for its activation and regulation’, Nature Communications. Nature Publishing Group, 9(1), p. 411. doi: 10.1038/s41467-017-02783-8. |
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