Search by BoMiProt ID - Bomi345

Primary Information

BoMiProt ID Bomi345
Protein Name SAM domain and HD domain-containing protein 1
Organism Bos taurus
Uniprot IDQ0VCA5
Milk FractionMFGM
Ref Sequence ID NP_001069329.1
Aminoacid Length 589
Molecular Weight 68239
FASTA Sequence Download
Gene Name SAMHD1
Gene ID 524683
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function dNTP phosphohydrolase restricts viral replication by limiting the cellular dNTP pool; Mg2+-dependent homotetrameric enzyme indiscriminately hydrolyzes all dNTPs to deoxynucleoside and tripolyphosphate products; plays a key role in an innate immunity pathway that restricts HIV-1 infection of resting immune cells by preventing efficient completion of reverse transcription
Biochemical Properties Two isoforms of mSAMHD1 resulting from alternative splicing share about 72–74% sequence identities with hSAMHD1; allosterically activated by nucleotides
Significance in milk involved in defense, immune and inflammatory reactions
PTMs Phosphoryalted: isoform 1 (iso1) has a phosphorylation site at residue T634
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions (1-41)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs regulates its antiviral activity
Bibliography 1. Seamon, K. J. et al. (2015) ‘SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity’, Nucleic Acids Research, 43(13), pp. 6486–6499. doi: 10.1093/nar/gkv633.
2. Buzovetsky, O. et al. (2018) ‘The SAM domain of mouse SAMHD1 is critical for its activation and regulation’, Nature Communications. Nature Publishing Group, 9(1), p. 411. doi: 10.1038/s41467-017-02783-8.