Search by BoMiProt ID - Bomi342

Primary Information

BoMiProt ID Bomi342
Protein Name Protein S100-B
Organism Bos taurus
Uniprot IDP02638
Milk FractionExosome
Ref Sequence ID NP_001029727.1
Aminoacid Length 92
Molecular Weight 10668
FASTA Sequence Download
Gene Name S100B
Gene ID 525716
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells S100B is expressed in astrocytes, certain neuronal populations, Schwann cells, melanocytes, chondrocytes, adipocytes, skeletal myofibers and associated satellite cells, certain dendritic cell and lymphocyte populations and a few other cell types;
Protein Function it acts as a cytokine with a neurotrophic effect at physiological concentrations; acts as a stimulator of cell proliferation and migration and an inhibitor of apoptosis and differentiation;have important implications during brain, cartilage and skeletal muscle development and regeneration/repair, activation of astrocytes in the course of brain damage and neurodegenerative processes, and of cardiomyocyte remodeling after infarction, as well as in melanomagenesis and gliomagenesis; regulate a large variety of key activities including maintenance of shape, transcription, protein degradation, Ca2+ homeostasis, energy metabolism and enzyme functions by interacting with a wide array of target proteins;
Biochemical Properties acidic calcium-binding protein of the EF-hand family, characterised by the most common calcium-binding motif of a helix–loop–helix structure; Binding partners of S100B within cells are tubulin and the microtubule-associated τ protein, the actin-binding protein caldesmon, calponin, type III intermediate filament subunits, annexin 6, membrane-bound guanylate cyclase, the small GTPase Rac1 and Cdc42 effector IQGAP1, Src kinase, the serine/threonine protein kinase Ndr, the tumor suppressor p53, intermediates upstream of IKKβ/NF-κB, the giant phosphoprotein AHNAK/desmoyokin, the E3 ligase hdm2, dopamine D2 receptor and the mitochondrial AAA ATPase, ATAD3A; changes in extracellular Ca2+ and K+ levels trigger release of S100B from astrocytes and fluoexitine stimulates S100B secretion from serotoninergic neurons;
Significance in milk Human milk S100B protein possesses important neurotrophic properties; As found in human milk, S100B concentration increases as the milk matures
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All alpha proteins
Fold : Pair of EF Hands-like
Superfamily : EF-hand
Family : S100 proteins
Domain Name : 3CR5 X:0-89

CATH Matched CATH superfamily
Predicted Disorder Regions 1-4,18-33,45-46,48-50,83-92
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 1CFP, 1MHO, 1PSB, 3CR2, 3CR4, 3CR5, 3GK1, 3GK2, 3GK4, 3IQO, 3IQQ, 3LK0, 3LK1, 3LLE, 3RLZ, 3RM1, 4FQO, 4PDZ, 4PE0, 4PE1, 4PE4, 4PE7, 5DKN, 5DKQ, 5DKR, 5ER4, 5ER5,
Bibliography 1. Gazzolo, D. et al. (2004) ‘Levels of S100B protein are higher in mature human milk than in colostrum and milk-formulae milks.’, Clinical nutrition (Edinburgh, Scotland), 23(1), pp. 23–6. Available at: (Accessed: 3 October 2019).
2. Hachem, S. et al. (2007) ‘Expression of S100B during embryonic development of the mouse cerebellum’, BMC Developmental Biology, 7(1), p. 17. doi: 10.1186/1471-213X-7-17.
3. Donato, R. (1984) ‘Mechanism of action of S-100 protein(s) on brain microtubule protein assembly.’, Biochemical and biophysical research communications, 124(3), pp. 850–6. doi: 10.1016/0006-291x(84)91035-0.
4. Gilquin, B. et al. (2010) ‘The Calcium-Dependent Interaction between S100B and the Mitochondrial AAA ATPase ATAD3A and the Role of This Complex in the Cytoplasmic Processing of ATAD3A’, Molecular and Cellular Biology, 30(11), pp. 2724–2736. doi: 10.1128/MCB.01468-09.