Search by BoMiProt ID - Bomi339

Primary Information

BoMiProt ID Bomi339
Protein Name Cytochrome b-c1 complex subunit 2, mitochondrial
Organism Bos taurus
Uniprot IDP23004
Milk FractionMFGM
Ref Sequence ID NP_001357536.1
Aminoacid Length 453
Molecular Weight 48149
FASTA Sequence Download
Gene Name UQCRC2
Gene ID 282394
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells localized to the inner mitochondrial membrane of eukaryotes or the cytoplasmic membrane of prokaryotic organisms
Protein Function catalyzes the reaction of transferring electrons from the low potential substrate ubiquinol to high potential cytochrome c; translocates protons across the membrane, contributing to the proton-motive force essential for a variety of cellular activities such as ATP synthesis; cyt bc1 complex catalyzes the antimycin-sensitive electron transfer (ET) reaction from lipophilic substrate ubiquinol (QH2) to cyt c coupled with proton translocation across the membrane;
Biochemical Properties multifunctional, bc1 is a dimer; membrane protein complex ; bc1 complex can be divided into three regions: the membrane spanning, the inter-membrane space (periplasm in bacteria or positive side of the membrane), and the matrix (cytoplasm in bacteria or negative side of the membrane) regions;
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : Alpha and beta proteins (a+b)
Fold : LuxS/MPP-like metallohydrolase
Superfamily : LuxS/MPP-like metallohydrolase
Family : MPP-like
Domain Name : 1PPJ B:17-235

CATH Matched CATH superfamily
Predicted Disorder Regions (25-35)
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 1BCC, 1BE3, 1BGY, 1L0L, 1L0N, 1NTK, 1NTM, 1NTZ, 1NU1, 1PP9, 1PPJ, 1QCR, 1SQB, 1SQP, 1SQQ, 1SQV, 1SQX, 2A06, 2BCC, 2FYU, 2YBB, 3BCC, 4D6T, 4D6U, 5GPN, 5KLV, 5LUF, 5NMI, 5OKD, 6FO0, 6FO2, 6FO6, 6HAW , 6NHG, 6XVF, 6ZFS, 6ZFT, 6ZFU,
Bibliography 1. Trumpower, B. L. and Gennis, R. B. (1994) ‘Energy Transduction by Cytochrome Complexes in Mitochondrial and Bacterial Respiration: The Enzymology of Coupling Electron Transfer Reactions to Transmembrane Proton Translocation’, Annual Review of Biochemistry, 63(1), pp. 675–716. doi: 10.1146/