Primary Information | |
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BoMiProt ID | Bomi339 |
Protein Name | Cytochrome b-c1 complex subunit 2, mitochondrial |
Organism | Bos taurus |
Uniprot ID | P23004 |
Milk Fraction | MFGM |
Ref Sequence ID | NP_001357536.1 |
Aminoacid Length | 453 |
Molecular Weight | 48149 |
FASTA Sequence | Download |
Gene Name | UQCRC2 |
Gene ID | 282394 |
Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
Presence in other biological fluids/tissue/cells | localized to the inner mitochondrial membrane of eukaryotes or the cytoplasmic membrane of prokaryotic organisms |
Protein Function | catalyzes the reaction of transferring electrons from the low potential substrate ubiquinol to high potential cytochrome c; translocates protons across the membrane, contributing to the proton-motive force essential for a variety of cellular activities such as ATP synthesis; cyt bc1 complex catalyzes the antimycin-sensitive electron transfer (ET) reaction from lipophilic substrate ubiquinol (QH2) to cyt c coupled with proton translocation across the membrane; |
Biochemical Properties | multifunctional, bc1 is a dimer; membrane protein complex ; bc1 complex can be divided into three regions: the membrane spanning, the inter-membrane space (periplasm in bacteria or positive side of the membrane), and the matrix (cytoplasm in bacteria or negative side of the membrane) regions; |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
SCOP | Class : Alpha and beta proteins (a+b) Fold : LuxS/MPP-like metallohydrolase Superfamily : LuxS/MPP-like metallohydrolase Family : MPP-like Domain Name : 1PPJ B:17-235 |
CATH | Matched CATH superfamily 3.30.830.10 |
Predicted Disorder Regions | (25-35) |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
PDB ID | 1BCC, 1BE3, 1BGY, 1L0L, 1L0N, 1NTK, 1NTM, 1NTZ, 1NU1, 1PP9, 1PPJ, 1QCR, 1SQB, 1SQP, 1SQQ, 1SQV, 1SQX, 2A06, 2BCC, 2FYU, 2YBB, 3BCC, 4D6T, 4D6U, 5GPN, 5KLV, 5LUF, 5NMI, 5OKD, 6FO0, 6FO2, 6FO6, 6HAW , 6NHG, 6XVF, 6ZFS, 6ZFT, 6ZFU, |
Bibliography | 1. Trumpower, B. L. and Gennis, R. B. (1994) ‘Energy Transduction by Cytochrome Complexes in Mitochondrial and Bacterial Respiration: The Enzymology of Coupling Electron Transfer Reactions to Transmembrane Proton Translocation’, Annual Review of Biochemistry, 63(1), pp. 675–716. doi: 10.1146/annurev.bi.63.070194.003331. |