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Primary Information | |
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| BoMiProt ID | Bomi339 |
| Protein Name | Cytochrome b-c1 complex subunit 2, mitochondrial |
| Organism | Bos taurus |
| Uniprot ID | P23004 |
| Milk Fraction | MFGM |
| Ref Sequence ID | NP_001357536.1 |
| Aminoacid Length | 453 |
| Molecular Weight | 48149 |
| FASTA Sequence | Download |
| Gene Name | UQCRC2 |
| Gene ID | 282394 |
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | localized to the inner mitochondrial membrane of eukaryotes or the cytoplasmic membrane of prokaryotic organisms |
| Protein Function | catalyzes the reaction of transferring electrons from the low potential substrate ubiquinol to high potential cytochrome c; translocates protons across the membrane, contributing to the proton-motive force essential for a variety of cellular activities such as ATP synthesis; cyt bc1 complex catalyzes the antimycin-sensitive electron transfer (ET) reaction from lipophilic substrate ubiquinol (QH2) to cyt c coupled with proton translocation across the membrane; |
| Biochemical Properties | multifunctional, bc1 is a dimer; membrane protein complex ; bc1 complex can be divided into three regions: the membrane spanning, the inter-membrane space (periplasm in bacteria or positive side of the membrane), and the matrix (cytoplasm in bacteria or negative side of the membrane) regions; |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| SCOP | Class : Alpha and beta proteins (a+b) Fold : LuxS/MPP-like metallohydrolase Superfamily : LuxS/MPP-like metallohydrolase Family : MPP-like Domain Name : 1PPJ B:17-235 |
| CATH | Matched CATH superfamily 3.30.830.10 |
| Predicted Disorder Regions | (25-35) |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1BCC, 1BE3, 1BGY, 1L0L, 1L0N, 1NTK, 1NTM, 1NTZ, 1NU1, 1PP9, 1PPJ, 1QCR, 1SQB, 1SQP, 1SQQ, 1SQV, 1SQX, 2A06, 2BCC, 2FYU, 2YBB, 3BCC, 4D6T, 4D6U, 5GPN, 5KLV, 5LUF, 5NMI, 5OKD, 6FO0, 6FO2, 6FO6, 6HAW , 6NHG, 6XVF, 6ZFS, 6ZFT, 6ZFU, |
| Bibliography | 1. Trumpower, B. L. and Gennis, R. B. (1994) ‘Energy Transduction by Cytochrome Complexes in Mitochondrial and Bacterial Respiration: The Enzymology of Coupling Electron Transfer Reactions to Transmembrane Proton Translocation’, Annual Review of Biochemistry, 63(1), pp. 675–716. doi: 10.1146/annurev.bi.63.070194.003331. |