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Primary Information | |
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| BoMiProt ID | Bomi338 |
| Protein Name | CD38 molecule |
| Organism | Bos taurus |
| Uniprot ID | Q9TTF5 |
| Milk Fraction | Exosome |
| Ref Sequence ID | NP_786992.1 |
| Aminoacid Length | 278 |
| Molecular Weight | 31546 |
| FASTA Sequence | Download |
| Gene Name | CD38 |
| Gene ID | 327677 |
| Protein Existence Status | Unreviewed: Experimental evidence at protein level |
Secondary Information | |
| Protein Function | human CD38 -transmembrane glycoprotein involved in lymphocyte activation and adhesion to endothelium; implicated in activities typical of cell surface receptors, such as signaling for activation and proliferation events and heterotypic cell adhesion; involved in the regulation of intracellular calcium levels in several cell systems |
| Biochemical Properties | ectocellular domain of the molecule possesses properties of a bifunctional enzyme catalyzing both the synthesis from NAD+ and the hydrolysis of the calcium-releasing metabolite cyclic ADP-ribose; |
| PTMs | Glycosylated: potential N-linked glycosylation sites asparagine residues, N100, N164, N209 and N219 |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >tr|Q9TTF5|Q9TTF5_BOVIN CD38 molecule OS=Bos taurus OX=9913 GN=CD38 PE=1 SV=1 MADCCTPRKKLCWCVLLFFLVAGITGGAIGIYKWHYSGLNRWHGAGSTADFQKIIQERCD TYTQTIRPGSRSRNCQAIRQAFMSAFISKDPCKATKEDYNSLINLAPPTVPCGQQVFWSK TKELAHEYAKRRRLMTLEDTLLGYLADGLRWCGEPGSSDLNIWSCPDWRKDCRTNYLSVF WEVLSERFAESACNTVRVVLN*201GSLENAFDSMSIFGRVE*218APNLRPQVELEAWLVHDTGKPP SDSCSGSSIRKLKSILDGRNVKFRCMDNLSRDQFLQRS |
| SCOP | Class : Alpha and beta proteins (a/b) Fold : Rossmann(2x3)oid (Flavodoxin-like) Superfamily : N-(deoxy)ribosyltransferase-like Family : ADP ribosyl cyclase-like Domain Name : 3KOU B:39-276 |
| CATH | Matched CATH superfamily 3.40.50.720 1.20.82.10 |
| Significance of PTMs | ADP-ribosyl cyclase activity of CD38 showed a decrease in the Vmax following its treatment with N-glycosidase F , the extracellular non-glycosylated form of CD38 was still fully active and exhibited both cyclase and hydrolase activities; Glycosylation prevents CD38 protein from forming inter-molecular cross-links |
| PDB ID | 3GC6, 3GH3, 3GHH, 3KOU, 3P5S, |
| Bibliography | 1. Gao, Y. and Mehta, K. (2007) ‘N-linked glycosylation of CD38 is required for its structure stabilization but not for membrane localization’, Molecular and Cellular Biochemistry, 295(1–2), pp. 1–7. doi: 10.1007/s11010-006-9265-9. 2. Fumaro, A. et al. (1996) ‘Identification and characterization of an active soluble form of human CD38 in normal and pathological fluids’, International Immunology. Narnia, 8(11), pp. 1643–1650. doi: 10.1093/intimm/8.11.1643. |