Primary Information |
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| BoMiProt ID | Bomi332 |
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| Protein Name | Solute carrier family 13 (Sodium-dependent dicarboxylate transporter), member 2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3SYV8 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001029406.1 |
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| Aminoacid Length | 592 |
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| Molecular Weight | 64980 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC13A2 |
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| Gene ID | 505069 |
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| Protein Existence Status | Unreviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | NaDC1 is located at the
brush border (apical) membrane of renal proximal
tubular and intestinal epithelial cells ; NaDC3 is primarily expressed at the basolateral
membrane of renal proximal tubular epithelial cells, expressed in liver,
placenta and brain |
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| Protein Function | Responsible for transport
of Krebs cycle intermediates and may involve in
regulation of aging and life span; involves in regulation of
urinary citrate, which acts as a calcium chelator to
inhibit the formation of kidney stones |
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| Biochemical Properties | contains 11 or 12 hydrophobic
transmembrane (TM) domains; based on their
substrate affinity, the transporters are classified into two
categories: low-affinity NaDC1 (SDCT1) and high-affinity
NaDC3 (SDCT2) |
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| Significance in milk | nutrient transport systems for milk precursors and constituents |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Bibliography | 1. Bai, X.-Y. et al. (2007) ‘Membrane topology structure of human high-affinity, sodium-dependent dicarboxylate transporter’, The FASEB Journal, 21(10), pp. 2409–2417. doi: 10.1096/fj.06-7652com.
2. Bai, X. et al. (2004) ‘Expression of EGFP/SDCT1 fusion protein, subcellular localization signal analysis, tissue distribution and electrophysiological function study.’, Science in China. Series C, Life sciences, 47(6), pp. 530–9. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15620109 (Accessed: 3 October 2019). |
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