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Primary Information | |
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| BoMiProt ID | Bomi330 |
| Protein Name | Spleen tyrosine kinase |
| Organism | Bos taurus |
| Uniprot ID | Q32PK0 |
| Milk Fraction | Exosome |
| Ref Sequence ID | NP_001032542.1 |
| Aminoacid Length | 605 |
| Molecular Weight | 69006 |
| FASTA Sequence | Download |
| Gene Name | SYK |
| Gene ID | 515515 |
| Protein Existence Status | Unreviewed: Experimental evidence at protein level |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | widely expressed in hematopoietic cells |
| Protein Function | Cytoplasmic non-receptor protein-tyrosine kinase; catalyzes the phosphorylation of proteins on tyrosines located at sites rich with acidic amino acids; plays an important role in signal transduction in a variety of cell types; pathogenic role of Syk in various allergic disorders, autoimmune diseases and malignancies; involved in coupling activated immunoreceptors to downstream signaling events that mediate cellular proliferation, differentiation and phagocytosis |
| Biochemical Properties | Contains a pair of Src homology 2 (SH2) domains at the N-terminus and a carboxy terminal tyrosine kinase domain; in inactive form, Syk assumes a closed, autoinhibited structure with the aromatic residues in interdomain A, B and the kinase domain interact to form a ‘linkerkinase sandwich’ |
| Significance in milk | regulates mammary epithelial cell proliferation in mammary glands of dairy cows |
| PTMs | Phosphorylated: As found in porcine spleen, had autophosphorylation activity |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| CATH | Matched CATH superfamily n/a |
| Significance of PTMs | phosphorylation of tyrosine activates Syk |
| PDB ID | 2FCI, |
| Bibliography | 1. Hou, X. et al. (2016) ‘Spleen tyrosine kinase regulates mammary epithelial cell proliferation in mammary glands of dairy cows’, Journal of Dairy Science, 99(5), pp. 3858–3868. doi: 10.3168/jds.2015-10118. |