Search by BoMiProt ID - Bomi330

Primary Information

BoMiProt ID Bomi330
Protein Name Spleen tyrosine kinase
Organism Bos taurus
Uniprot IDQ32PK0
Milk FractionExosome
Ref Sequence ID NP_001032542.1
Aminoacid Length 605
Molecular Weight 69006
FASTA Sequence Download
Gene Name SYK
Gene ID 515515
Protein Existence Status Unreviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells widely expressed in hematopoietic cells
Protein Function Cytoplasmic non-receptor protein-tyrosine kinase; catalyzes the phosphorylation of proteins on tyrosines located at sites rich with acidic amino acids; plays an important role in signal transduction in a variety of cell types; pathogenic role of Syk in various allergic disorders, autoimmune diseases and malignancies; involved in coupling activated immunoreceptors to downstream signaling events that mediate cellular proliferation, differentiation and phagocytosis
Biochemical Properties Contains a pair of Src homology 2 (SH2) domains at the N-terminus and a carboxy terminal tyrosine kinase domain; in inactive form, Syk assumes a closed, autoinhibited structure with the aromatic residues in interdomain A, B and the kinase domain interact to form a ‘linkerkinase sandwich’
Significance in milk regulates mammary epithelial cell proliferation in mammary glands of dairy cows
PTMs Phosphorylated: As found in porcine spleen, had autophosphorylation activity
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
CATH Matched CATH superfamily
Significance of PTMs phosphorylation of tyrosine activates Syk
Bibliography 1. Hou, X. et al. (2016) ‘Spleen tyrosine kinase regulates mammary epithelial cell proliferation in mammary glands of dairy cows’, Journal of Dairy Science, 99(5), pp. 3858–3868. doi: 10.3168/jds.2015-10118.