Primary Information | |
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BoMiProt ID | Bomi330 |
Protein Name | Spleen tyrosine kinase |
Organism | Bos taurus |
Uniprot ID | Q32PK0 |
Milk Fraction | Exosome |
Ref Sequence ID | NP_001032542.1 |
Aminoacid Length | 605 |
Molecular Weight | 69006 |
FASTA Sequence | Download |
Gene Name | SYK |
Gene ID | 515515 |
Protein Existence Status | Unreviewed: Experimental evidence at protein level |
Secondary Information | |
Presence in other biological fluids/tissue/cells | widely expressed in hematopoietic cells |
Protein Function | Cytoplasmic non-receptor protein-tyrosine kinase; catalyzes the phosphorylation of proteins on tyrosines located at sites rich with acidic amino acids; plays an important role in signal transduction in a variety of cell types; pathogenic role of Syk in various allergic disorders, autoimmune diseases and malignancies; involved in coupling activated immunoreceptors to downstream signaling events that mediate cellular proliferation, differentiation and phagocytosis |
Biochemical Properties | Contains a pair of Src homology 2 (SH2) domains at the N-terminus and a carboxy terminal tyrosine kinase domain; in inactive form, Syk assumes a closed, autoinhibited structure with the aromatic residues in interdomain A, B and the kinase domain interact to form a ‘linkerkinase sandwich’ |
Significance in milk | regulates mammary epithelial cell proliferation in mammary glands of dairy cows |
PTMs | Phosphorylated: As found in porcine spleen, had autophosphorylation activity |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
CATH | Matched CATH superfamily n/a |
Significance of PTMs | phosphorylation of tyrosine activates Syk |
PDB ID | 2FCI, |
Bibliography | 1. Hou, X. et al. (2016) ‘Spleen tyrosine kinase regulates mammary epithelial cell proliferation in mammary glands of dairy cows’, Journal of Dairy Science, 99(5), pp. 3858–3868. doi: 10.3168/jds.2015-10118. |