Primary Information
BoMiProt ID	Bomi33
Protein Name	Peptidoglycan recognition protein 1
Organism	Bos taurus
Uniprot ID	Q8SPP7
Milk Fraction	Whey
Ref Sequence ID	NP_776998.1
Aminoacid Length	190
Molecular Weight	21063
FASTA Sequence	Download
Gene Name	PGLYRP1
Gene ID	282305
Protein Existence Status	Reviewed: Experimental evidence at protein level
Secondary Information
Presence in other biological fluids/tissue/cells	neutrophils, eosinophil, bone marrow, fetal liver
Protein Function	pattern recognition molecules of innate immunity; bind bacterial molecules and kill in peptidoglycan independent manner; recognizes multiple microbial components
Biochemical Properties	highest affinity for lipopolysaccharide; significant affinity for lipotechoic acid and little for peptidoglycan in killing inhibition assays; MgCl2 or CaCl2 as low as 0.8 mM ablate bPGRP-S-mediated killing of S. typhimurium; bPGRP-S has a serine substitution at a cysteine residue predicted to stabilize a zinc ion; PGRP in camel ripe and porcine colostral milk is a 19-kDa monomeric protein;
Significance in milk	As found in camel milk it exhibits udder protection; control lactic acid bacteria; upregulated in cases of mastitis; avidly bound to lactic acid bacteria, and the protein was markedly upregulated in the case of streptococcal infection;
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	In mammals, PRPs are differentially expressed in the bone marrow, liver, and esophagus where they are likely to play a role in recognition of bacteria
Bibliography	1. Kappeler, S. R., Heuberger, C., Farah, Z., & Puhan, Z. (2004). Expression of the peptidoglycan recognition protein, PGRP, in the lactating mammary gland. Journal of Dairy Science, 87(8), 2660–2668. https://doi.org/10.3168/jds.S0022-0302(04)73392-5. 2. Dziarski, R. (2004). Peptidoglycan recognition proteins (PGRPs). Molecular Immunology, 40(12), 877–886. https://doi.org/10.1016/j.molimm.2003.10.011. 3. Tydell, C. C., Yuan, J., Tran, P., & Selsted, M. E. (2006). Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties. Journal of Immunology (Baltimore, Md. : 1950), 176(2), 1154–1162. https://doi.org/10.4049/jimmunol.176.2.1154.