Search by BoMiProt ID - Bomi33

Primary Information

BoMiProt ID Bomi33
Protein Name Peptidoglycan recognition protein 1
Organism Bos taurus
Uniprot IDQ8SPP7
Milk FractionWhey
Ref Sequence ID NP_776998.1
Aminoacid Length 190
Molecular Weight 21063
FASTA Sequence Download
Gene Name PGLYRP1
Gene ID 282305
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells neutrophils, eosinophil, bone marrow, fetal liver
Protein Function pattern recognition molecules of innate immunity; bind bacterial molecules and kill in peptidoglycan independent manner; recognizes multiple microbial components
Biochemical Properties highest affinity for lipopolysaccharide; significant affinity for lipotechoic acid and little for peptidoglycan in killing inhibition assays; MgCl2 or CaCl2 as low as 0.8 mM ablate bPGRP-S-mediated killing of S. typhimurium; bPGRP-S has a serine substitution at a cysteine residue predicted to stabilize a zinc ion; PGRP in camel ripe and porcine colostral milk is a 19-kDa monomeric protein;
Significance in milk As found in camel milk it exhibits udder protection; control lactic acid bacteria; upregulated in cases of mastitis; avidly bound to lactic acid bacteria, and the protein was markedly upregulated in the case of streptococcal infection;
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments In mammals, PRPs are differentially expressed in the bone marrow, liver, and esophagus where they are likely to play a role in recognition of bacteria
Bibliography 1. Kappeler, S. R., Heuberger, C., Farah, Z., & Puhan, Z. (2004). Expression of the peptidoglycan recognition protein, PGRP, in the lactating mammary gland. Journal of Dairy Science, 87(8), 2660–2668.
2. Dziarski, R. (2004). Peptidoglycan recognition proteins (PGRPs). Molecular Immunology, 40(12), 877–886.
3. Tydell, C. C., Yuan, J., Tran, P., & Selsted, M. E. (2006). Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties. Journal of Immunology (Baltimore, Md. : 1950), 176(2), 1154–1162.