Primary Information |
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| BoMiProt ID | Bomi3233 |
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| Protein Name | Nucleoside diphosphate kinase A 1 |
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| Organism | Bos taurus |
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| Uniprot ID | P52174 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 152 |
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| Molecular Weight | 17261 |
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| FASTA Sequence |
Download |
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| Gene Name | NME1-1 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | NDPK plays a primary role not only in maintaining cellular pools of all NTPs but also in the regulation of important cellular processes. NDPK-A (or Nm23-H1), one of eight human NDPKs, acts as a metastasis suppressor for some tumour types. |
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| Biochemical Properties | NDPK-A revealed a homohexameric structure stabilized by cross-interaction between the Kpn loop region and the neighbouring C-terminal domain. However, a large proportion of the native homohexameric form of NDPK-A with full NDPK activity disappears upon disulfide cross-linking, with a concomitant increase in the inactive dimeric form. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| PDB ID | 1BHN, |
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| Additional Comments | over-expression of nucleoside diphosphate kinase A (NDKA) in tumours and serum from colorectal cancer (CRC) patients, suggesting its use as biomarker. |
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| Bibliography | 1.Kim MS, Jeong J, Lee KJ, Shin DH. A preliminary X-ray study of human nucleoside diphosphate kinase A under oxidative conditions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1490-2. doi: 10.1107/S1744309110036067. Epub 2010 Oct 28. PMID: 21045303; PMCID: PMC3001656. 2.Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor.Min K, Song HK, Chang C, Kim SY, Lee KJ, Suh SW Proteins. 2002 Feb 15; 46(3):340-2. |
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