Search by BoMiProt ID - Bomi3233

Primary Information

BoMiProt ID Bomi3233
Protein Name Nucleoside diphosphate kinase A 1
Organism Bos taurus
Uniprot IDP52174
Milk FractionWhey
Aminoacid Length 152
Molecular Weight 17261
FASTA Sequence Download
Gene Name NME1-1
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function NDPK plays a primary role not only in maintaining cellular pools of all NTPs but also in the regulation of important cellular processes. NDPK-A (or Nm23-H1), one of eight human NDPKs, acts as a metastasis suppressor for some tumour types.
Biochemical Properties NDPK-A revealed a homohexameric structure stabilized by cross-interaction between the Kpn loop region and the neighbouring C-terminal domain. However, a large proportion of the native homohexameric form of NDPK-A with full NDPK activity disappears upon disulfide cross-linking, with a concomitant increase in the inactive dimeric form.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments over-expression of nucleoside diphosphate kinase A (NDKA) in tumours and serum from colorectal cancer (CRC) patients, suggesting its use as biomarker. 
Bibliography 1.Kim MS, Jeong J, Lee KJ, Shin DH. A preliminary X-ray study of human nucleoside diphosphate kinase A under oxidative conditions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1490-2. doi: 10.1107/S1744309110036067. Epub 2010 Oct 28. PMID: 21045303; PMCID: PMC3001656. 2.Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor.Min K, Song HK, Chang C, Kim SY, Lee KJ, Suh SW Proteins. 2002 Feb 15; 46(3):340-2.