Primary Information |
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| BoMiProt ID | Bomi3230 |
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| Protein Name | Palmitoyl-protein thioesterase 1 |
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| Organism | Bos taurus |
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| Uniprot ID | P45478 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776579.1 |
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| Aminoacid Length | 306 |
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| Molecular Weight | 34142 |
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| FASTA Sequence |
Download |
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| Gene Name | PPT1 |
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| Gene ID | 281421 |
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| Protein Existence Status | Reveiwed:Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | Palmitoyl protein thioesterase 1 (PPT1), a lysosomal enzyme, is involved in removing thioester-linked fatty acid groups from modified cysteine residues in proteins. |
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| Biochemical Properties | PPT predicts a protein of 306 amino acids that contains amino acid motifs characteristic of thioesterases: "Gly-X-Ser-X-Gly" positioned near the NH2 terminus and "Gly-Asp-His" positioned near the COOH terminus of the protein. |
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| PTMs | Disulfide bond formation,N-Linked Glycosylation at Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| PDB ID | 1EH5, 1EI9, 1EXW, |
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| Bibliography | 1.Camp LA, Verkruyse LA, Afendis SJ, Slaughter CA, Hofmann SL. Molecular cloning and expression of palmitoyl-protein thioesterase. J Biol Chem. 1994 Sep 16;269(37):23212-9. PMID: 7916016. 2.Yun HR, Jo YH, Kim J, Nguyen NNY, Shin Y, Kim SS, Choi TG. Palmitoyl Protein Thioesterase 1 Is Essential for Myogenic Autophagy of C2C12 Skeletal Myoblast. Front Physiol. 2020 Oct 15;11:569221. doi: 10.3389/fphys.2020.569221. PMID: 33178040; PMCID: PMC7593845. |
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