Search by BoMiProt ID - Bomi3230

Primary Information

BoMiProt ID Bomi3230
Protein Name Palmitoyl-protein thioesterase 1
Organism Bos taurus
Uniprot IDP45478
Milk FractionWhey
Ref Sequence ID NP_776579.1
Aminoacid Length 306
Molecular Weight 34142
FASTA Sequence Download
Gene Name PPT1
Gene ID 281421
Protein Existence Status Reveiwed:Experimental evidence at protein level

Secondary Information

Protein Function Palmitoyl protein thioesterase 1 (PPT1), a lysosomal enzyme, is involved in removing thioester-linked fatty acid groups from modified cysteine residues in proteins.
Biochemical Properties PPT predicts a protein of 306 amino acids that contains amino acid motifs characteristic of thioesterases: "Gly-X-Ser-X-Gly" positioned near the NH2 terminus and "Gly-Asp-His" positioned near the COOH terminus of the protein. 
PTMs Disulfide bond formation,N-Linked Glycosylation at Asn
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 1EH5, 1EI9, 1EXW,
Bibliography 1.Camp LA, Verkruyse LA, Afendis SJ, Slaughter CA, Hofmann SL. Molecular cloning and expression of palmitoyl-protein thioesterase. J Biol Chem. 1994 Sep 16;269(37):23212-9. PMID: 7916016. 2.Yun HR, Jo YH, Kim J, Nguyen NNY, Shin Y, Kim SS, Choi TG. Palmitoyl Protein Thioesterase 1 Is Essential for Myogenic Autophagy of C2C12 Skeletal Myoblast. Front Physiol. 2020 Oct 15;11:569221. doi: 10.3389/fphys.2020.569221. PMID: 33178040; PMCID: PMC7593845.