Search by BoMiProt ID - Bomi319

Primary Information

BoMiProt ID Bomi319
Protein Name Proteasome assembly chaperone 2
Organism Bos taurus
Uniprot IDQ2NL24
Milk FractionExosome
Ref Sequence ID NP_001039830.1
Aminoacid Length 264
Molecular Weight 29224
FASTA Sequence Download
Gene Name PSMG2
Gene ID 533993
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function regulates assembly of its catalytic 20S core particle
Biochemical Properties As found in human, proteasome-assembling chaperon PAC4 has a hydrophobic surface that is surrounded by charged residues; The hydrophobic surface is complementary to that of its binding partner, PAC3; The surface also exhibits charge complementarity with the proteasomal a4–5 subunits; Hydrophobic patches are commonly found in the centers of b-sheet surfaces that forms PAC3–PAC4 interface; PAC4 forms a heterodimeric complex with PAC3 through its hydrophobic surface surrounded by the charged residues; PAC3 interface is dimeric which can be a target of inhibitors against chaperone dimerization
Significance in milk Higher expression indicate enhanced mammary protein catabolism in cows
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Kurimoto, E. et al. (2017) ‘Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation’, Protein Science, 26(5), pp. 1080–1085. doi: 10.1002/pro.3153.