Search by BoMiProt ID - Bomi315

Primary Information

BoMiProt ID Bomi315
Protein Name Serine/threonine-protein kinase N1
Organism Bos taurus
Uniprot IDA1A4I4
Milk FractionExosome
Ref Sequence ID NP_001073715.1
Aminoacid Length 944
Molecular Weight 104133
FASTA Sequence Download
Gene Name PKN1
Gene ID 509080
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function Interact with diverse substrates ranging from enzymes, including other kinases, to transcription factors, receptors, and other regulatory proteins
Significance in milk Increase in protein supports milk protein synthesis during the periparturient period
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 528-547, 557-607, 764-794, 898-909
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Ma, Y. F. et al. (2019) ‘Phosphorylation of AKT serine/threonine kinase and abundance of milk protein synthesis gene networks in mammary tissue in response to supply of methionine in periparturient Holstein cows’, Journal of Dairy Science, 102(5), pp. 4264–4274. doi: 10.3168/jds.2018-15451.
2. Nerstedt, A. et al. (2012) ‘Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle’, Diabetologia, 55(6), pp. 1797–1807. doi: 10.1007/s00125-012-2511-7.
3. Manning, G. et al. (2002) ‘The Protein Kinase Complement of the Human Genome’, Science, 298(5600), pp. 1912–1934. doi: 10.1126/science.1075762.