Search by BoMiProt ID - Bomi307

Primary Information

BoMiProt ID Bomi307
Protein Name Myosin-Id
Organism Bos taurus
Uniprot IDQ17R14
Milk FractionWhey, MFGM, Exosome
Ref Sequence ID NP_001069306.1
Aminoacid Length 1006
Molecular Weight 115939
FASTA Sequence Download
Gene Name MYO1D
Gene ID 522967
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells found in a wide range of tissues, but highly expressed in the nervous system
Protein Function plays a role in membrane trafficking, control of membrane tension and the establishment of left-right asymmetry during Drosophila development; important role in nervous system tissues; enriched component of the myelin proteome
Biochemical Properties monomeric actin-based motor; bind directly to acidic phospholipids via a C-terminal basic domain; presence of two IQ motifs that bind calmodulin in rat myosin 1d; Myo1d ATPase activity is regulated by its light chain binding domain and the associated light chain CaM; CaM binds in a cooperative manner to the light chain binding domain of Myo1d
Significance in milk Cytoskeletal proteins; found increased during infection
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Köhler, D., Struchholz, S. and Bähler, M. (2005) ‘The two IQ-motifs and Ca2+/calmodulin regulate the rat myosin 1d ATPase activity’, FEBS Journal, 272(9), pp. 2189–2197. doi: 10.1111/j.1742-4658.2005.04642.x.
2. Benesh, A. E. et al. (2012) ‘Expression and localization of myosin-1d in the developing nervous system’, Brain Research, 1440, pp. 9–22. doi: 10.1016/j.brainres.2011.12.054.