Search by BoMiProt ID - Bomi306

Primary Information

BoMiProt ID Bomi306
Protein Name Myosin-Ic
Organism Bos taurus
Uniprot IDQ27966
Milk FractionMFGM, Exosome
Ref Sequence ID NP_776821.3
Aminoacid Length 1063
Molecular Weight 121936
FASTA Sequence Download
Gene Name MYO1C
Gene ID 281937
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function widely expressed motor protein that links the actin cytoskeleton to cell membranes, has been associated with numerous cellular processes, including insulin-stimulated transport of GLUT4, mechanosensation in sensory hair cells, endocytosis, transcription of DNA in the nucleus, exocytosis, and membrane trafficking;
Biochemical Properties low duty ratio motor; approximately 10-fold longer than the processive motor, myosin-V; actin-attachment lifetime is insensitive to low forces (<1 pN), but very sensitive to higher loads (>1 pN) that resist the powerstroke where increasing force on the myosin increases the attachment lifetime
Significance in milk Cytoskeletal proteins; found increased during infection
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Greenberg, M. J. et al. (2012) ‘Myosin IC generates power over a range of loads via a new tension-sensing mechanism.’, Proceedings of the National Academy of Sciences of the United States of America, 109(37), pp. E2433-40. doi: 10.1073/pnas.1207811109.