Primary Information |
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| BoMiProt ID | Bomi306 |
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| Protein Name | Myosin-Ic |
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| Organism | Bos taurus |
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| Uniprot ID | Q27966 |
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| Milk Fraction | MFGM, Exosome |
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| Ref Sequence ID | NP_776821.3 |
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| Aminoacid Length | 1063 |
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| Molecular Weight | 121936 |
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| FASTA Sequence |
Download |
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| Gene Name | MYO1C |
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| Gene ID | 281937 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | widely expressed motor protein that links the
actin cytoskeleton to cell membranes, has been associated with
numerous cellular processes, including insulin-stimulated transport
of GLUT4, mechanosensation in sensory hair cells, endocytosis,
transcription of DNA in the nucleus, exocytosis, and membrane
trafficking; |
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| Biochemical Properties | low duty
ratio motor; approximately 10-fold longer than
the processive motor, myosin-V; actin-attachment lifetime
is insensitive to low forces (<1 pN), but very sensitive to higher
loads (>1 pN) that resist the powerstroke where increasing force
on the myosin increases the attachment lifetime |
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| Significance in milk | Cytoskeletal proteins; found increased during infection |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1. Greenberg, M. J. et al. (2012) ‘Myosin IC generates power over a range of loads via a new tension-sensing mechanism.’, Proceedings of the National Academy of Sciences of the United States of America, 109(37), pp. E2433-40. doi: 10.1073/pnas.1207811109. |
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