Primary Information |
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| BoMiProt ID | Bomi299 |
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| Protein Name | Casein kinase I isoform gamma-1 |
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| Organism | Bos taurus |
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| Uniprot ID | A7E3X2 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001033235.1 |
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| Aminoacid Length | 457 |
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| Molecular Weight | 52620 |
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| FASTA Sequence |
Download |
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| Gene Name | CSNK1G1 |
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| Gene ID | 527889 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | golgi fractions of liver, spleen, kidney and brain |
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| Protein Function | phosphorylates caseins which is
important to allow them to bind Ca2+ and for the subsequent
formation of casein micelles, which remain stable in milk |
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| Biochemical Properties | cytosolic enzymes; the specific activities of casein kinase
are 1433 and 30.6 pmoles/min per mg of
protein in Golgi and milk respectively, giving a ratio of 47.7:1; activity inhibited by Mn2+ |
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| Significance in milk | Phosphorylates any non-phosphorylated
casein that is secreted and stored within the lumen of mammary
alveoli |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | (1-36), (350-384) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1. Duncan, J. S., Wilkinson, M. C. and Burgoyne, R. D. (2000) ‘Purification of Golgi casein kinase from bovine milk.’, The Biochemical journal, 350 Pt 2, pp. 463–8. Available at: http://www.ncbi.nlm.nih.gov/pubmed/10947960 (Accessed: 4 October 2019). |
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