Search by BoMiProt ID - Bomi295

Primary Information

BoMiProt ID Bomi295
Protein Name Ubiquitin-like protein ISG15
Organism Bos taurus
Uniprot IDO02741
Milk FractionMFGM
Ref Sequence ID NP_776791.1
Aminoacid Length 154
Molecular Weight 17310
FASTA Sequence Download
Gene Name ISG15
Gene ID 281871
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function Interferon-induced protein; covalently ligated to intracellular proteins in a parallel enzymatic reaction; target distinct subsets of intracellular proteins; participates in a number of fundamental regulatory processes through a unique posttranslational modification in which the carboxyl terminus of the polypeptide is covalently ligated to primary amines on a variety of intracellular proteins; participates in degradative targeting
PTMs UCRP is synthesized as precursors that undergo co- or posttranslational processing to yield identical carboxyl-terminal sequences of Leu-Arg-Leu-Arg-Gly-Gly
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs hexapeptide sequence is functionally significant, since it is the site of isopeptide bond formation to ubiquitin contributes to interactions with several ubiquitin-specific proteins such as the carboxyl-terminal hydrolases and other enzymes required for target protein conjugation
Bibliography 1. Loeb, K. R. and Haas, A. L. (1994) ‘Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern.’, Molecular and cellular biology, 14(12), pp. 8408–19. doi: 10.1128/mcb.14.12.8408.