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Primary Information | |
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| BoMiProt ID | Bomi295 |
| Protein Name | Ubiquitin-like protein ISG15 |
| Organism | Bos taurus |
| Uniprot ID | O02741 |
| Milk Fraction | MFGM |
| Ref Sequence ID | NP_776791.1 |
| Aminoacid Length | 154 |
| Molecular Weight | 17310 |
| FASTA Sequence | Download |
| Gene Name | ISG15 |
| Gene ID | 281871 |
| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
Secondary Information | |
| Protein Function | Interferon-induced protein; covalently ligated to intracellular proteins in a parallel enzymatic reaction; target distinct subsets of intracellular proteins; participates in a number of fundamental regulatory processes through a unique posttranslational modification in which the carboxyl terminus of the polypeptide is covalently ligated to primary amines on a variety of intracellular proteins; participates in degradative targeting |
| PTMs | UCRP is synthesized as precursors that undergo co- or posttranslational processing to yield identical carboxyl-terminal sequences of Leu-Arg-Leu-Arg-Gly-Gly |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| Significance of PTMs | hexapeptide sequence is functionally significant, since it is the site of isopeptide bond formation to ubiquitin contributes to interactions with several ubiquitin-specific proteins such as the carboxyl-terminal hydrolases and other enzymes required for target protein conjugation |
| PDB ID | 2BX0, |
| Bibliography | 1. Loeb, K. R. and Haas, A. L. (1994) ‘Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern.’, Molecular and cellular biology, 14(12), pp. 8408–19. doi: 10.1128/mcb.14.12.8408. |