Primary Information
BoMiProt ID	Bomi291
Protein Name	Heat shock protein 105 kDa
Organism	Bos taurus
Uniprot ID	Q0IIM3
Milk Fraction	MFGM, Exosome
Ref Sequence ID	NP_001068770.1
Aminoacid Length	859
Molecular Weight	96726
FASTA Sequence	Download
Gene Name	HSPH1
Gene ID	507165
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Presence in other biological fluids/tissue/cells	105-kDa heat-shock protein (HSP105) as a mammalian high molecular mass heat-shock protein in human, mouse, and rat cells; moderately expressed in adrenal, spleen, liver, lung, and heart; Small amounts of HSP105 are expressed in the kidney, stomach, muscle, testis, and lens. However, in brain HSP105-a was characteristically highly expressed over HSP105-b
Protein Function	induced in various tissues of rat after whole-body hyperthermia; HSP105 level of HSP10S increased markedly in the embryos from gestational day (GD) 9 to 11, then decreased gradually by GD 14; plays important roles in mouse embryogenesis; prevent the aggregation of heat-denatured proteins in vitro;
Biochemical Properties	HSPI05 is composed of two isoforms with slightly different isoelectric points with slightly different isoelectric points, acidic and basic isoforms; mRNA was also induced by azetidine-2-carboxylic acid, sodium arsenite, zinc sulfate, and cupric sulfate;
Significance in milk	heat stress proteins in mamary gland
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	515-585,797-859
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	sensitive to heat stress and mainly responsible for mammary cell protection from heat stress
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