Search by BoMiProt ID - Bomi289

Primary Information

BoMiProt ID Bomi289
Protein Name Solute carrier family 2, facilitated glucose transporter member 1
Organism Bos taurus
Uniprot IDP27674
Milk FractionExosome
Ref Sequence ID NP_777027.1
Aminoacid Length 492
Molecular Weight 54132
FASTA Sequence Download
Gene Name SLC2A1
Gene ID 282356
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells widely distributed and are present on the surface of probably all mammalian cells; highest levels are in placenta, brain, and kidney
Protein Function catalyses facilitative diffusion of glucose into erythrocytes and is responsible for glucose supply to the brain and other organs; mediates the basal-level cellular uptake of glucose into many tissues; functionally important either for transport of glucose or for the regulation of transport activity
Biochemical Properties belongs to the sugar porter subfamily of the major facilitator superfamily; comprises 12 transmembrane segments organized into two discretely folded domains, namely the amino- and carboxy-terminaldomains; extracellular loop of 33 amino acids connects transmembrane segments M1 and M2
Significance in milk nutrient transport systems for milk precursors and constituents
PTMs Glycosylated: M1 and M2 and contains a potential site for asparagine-linked gloycosylation (Asn-Xaa- Thr/Ser; Fig. 2)
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-8,241-251,471-492
DisProt Annotation
TM Helix Prediction 12TMHs; (13-35),(65-87),(94-112),(121-143),(154-176),(185-207),(272-294),(306-328),(335-357),(369-391),(402-424),(428-450)
Bibliography 1. Deng, D. et al. (2014) ‘Crystal structure of the human glucose transporter GLUT1’, Nature, 510(7503), pp. 121–125. doi: 10.1038/nature13306.
2. Mueckler, M. et al. (1985) ‘Sequence and structure of a human glucose transporter’, Science, 229(4717), pp. 941–945. doi: 10.1126/science.3839598.
3. Thorens, B. et al. (1988) ‘Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells’, Cell, 55(2), pp. 281–290. doi: 10.1016/0092-8674(88)90051-7.