Search by BoMiProt ID - Bomi286

Primary Information

BoMiProt ID Bomi286
Protein Name Coagulation factor IX (Fragment)
Organism Bos taurus
Uniprot IDP00741
Milk FractionWhey
Aminoacid Length 462
Molecular Weight 52046
FASTA Sequence Download
Gene Name F9
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function plasma glycoprotein which participates in the middle phase of intrinsic blood coagulation; During coagulation, factor IX is converted to an enzyme,factor IX;l, by factor XIa- Factor IXa then converts factor X (Stuart factor) to factor Xa in the presence of factor VIII. Factor IX is a factor of the blood coagulation system. Its activation occurs on the surface of phospholipid membranes. 
Biochemical Properties single polypeptide chain with an amino-terminal sequence of Tyr-Asn-Ser-Gly; isoelectric point is 3.7; binds to Dextran Blue in the presence of calcium ions; susceptible to minor protease degradation by plasma enzymes
PTMs Glycosylated: contains approximately 26% carbohydrate which includes 10.6% hexose, 6.5% V-acetylhexosamine, and 8.7% V-acetyIncuraminic acid;
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
>sp|P00741|FA9_BOVIN Coagulation factor IX OS=Bos taurus OX=9913 GN=F9 PE=1 SV=2
SCOP Class : Small proteins;Proteins with little or no secondary structures.
Fold : GLA-domain
Superfamily : GLA-domain
Family : GLA-domain
Domain Name : 1J34 C:401-446

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs high carbohydrate content of factor IX, a carbohydrate heparin interaction bridged by calcium ions is possible
PDB ID 1J34, 1J35,
Bibliography 1. Fujikawa, K. et al. (1973) ‘Isolation and characterization of bovine factor IX (Christmas factor)’, Biochemistry, 12(24), pp. 4938–4945. doi: 10.1021/bi00748a019.
2. Fujikawa, K. et al. (1974) ‘Mechanism of activation of bovine factor IX (Christmas factor) by bovine factor XIa(activated plasma thromboplastin antecedent)’, Biochemistry, 13(22), pp. 4508–4516. doi: 10.1021/bi00719a006. 2.Taran LD. Factor IX of the blood coagulation system: a review. Biochemistry (Mosc). 1997 Jul;62(7):685-93. PMID: 9331959.