Search by BoMiProt ID - Bomi2779

Primary Information

BoMiProt ID Bomi2779
Protein Name Transcobalamin-2
Organism Bos taurus
Uniprot IDQ9XSC9
Milk FractionWhey, Exosome
Ref Sequence ID NP_776620.2
Aminoacid Length 432
Molecular Weight 47958
FASTA Sequence Download
Gene Name TCN2
Gene ID 281518
Protein Existence Status Reveiwed:Experimental evidence at protein level

Secondary Information

Protein Function Transcobalamin II is a plasma protein that binds vitamin B12 (cobalamin) as it is absorbed in the terminal ileum and distributes it to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis. 
PTMs Disulfide bond formation,N-Linked Glycosylation at Asn
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Rothenberg SP, Quadros EV. Transcobalamin II and the membrane receptor for the transcobalamin II-cobalamin complex. Baillieres Clin Haematol. 1995 Sep;8(3):499-514. doi: 10.1016/s0950-3536(05)80218-5. PMID: 8534959.