Primary Information |
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| BoMiProt ID | Bomi2779 |
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| Protein Name | Transcobalamin-2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q9XSC9 |
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| Milk Fraction | Whey, Exosome |
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| Ref Sequence ID | NP_776620.2 |
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| Aminoacid Length | 432 |
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| Molecular Weight | 47958 |
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| FASTA Sequence |
Download |
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| Gene Name | TCN2 |
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| Gene ID | 281518 |
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| Protein Existence Status | Reveiwed:Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | Transcobalamin II is a plasma protein that binds vitamin B12 (cobalamin) as it is absorbed in the terminal ileum and distributes it to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis. |
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| PTMs | Disulfide bond formation,N-Linked Glycosylation at Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Rothenberg SP, Quadros EV. Transcobalamin II and the membrane receptor for the transcobalamin II-cobalamin complex. Baillieres Clin Haematol. 1995 Sep;8(3):499-514. doi: 10.1016/s0950-3536(05)80218-5. PMID: 8534959. |
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