Primary Information |
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| BoMiProt ID | Bomi2773 |
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| Protein Name | Tubulin alpha-1D chain |
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| Organism | Bos taurus |
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| Uniprot ID | Q2HJ86 |
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| Milk Fraction | MFGM, Exosome |
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| Ref Sequence ID | NP_001039875.1 |
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| Aminoacid Length | 452 |
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| Molecular Weight | 50283 |
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| FASTA Sequence |
Download |
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| Gene Name | TUBA1D |
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| Gene ID | 535605 |
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| Protein Existence Status | Reveiwed:Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain |
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| PTMs | N6-Acetylation Lys, Isopeptide bond, Methylation, Nitration at Tyr, Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | (433-452) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen,which increases microtubule stability, intracellular transport and ciliary assembly.Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.Nitration of Tyr-452 is irreversible and interferes with normal dynein intracellular distribution. |
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