Search by BoMiProt ID - Bomi2773

Primary Information

BoMiProt ID Bomi2773
Protein Name Tubulin alpha-1D chain
Organism Bos taurus
Uniprot IDQ2HJ86
Milk FractionMFGM, Exosome
Ref Sequence ID NP_001039875.1
Aminoacid Length 452
Molecular Weight 50283
FASTA Sequence Download
Gene Name TUBA1D
Gene ID 535605
Protein Existence Status Reveiwed:Experimental evidence at protein level

Secondary Information

Protein Function Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain 
PTMs N6-Acetylation Lys, Isopeptide bond, Methylation, Nitration at Tyr, Phosphorylation at Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions (433-452)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen,which increases microtubule stability, intracellular transport and ciliary assembly.Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.Nitration of Tyr-452 is irreversible and interferes with normal dynein intracellular distribution.