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Primary Information | |
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| BoMiProt ID | Bomi273 |
| Protein Name | Aspartyl aminopeptidase |
| Organism | Bos taurus |
| Uniprot ID | Q2HJH1 |
| Milk Fraction | Exosome |
| Ref Sequence ID | NP_001039417.1 |
| Aminoacid Length | 471 |
| Molecular Weight | 51828 |
| FASTA Sequence | Download |
| Gene Name | DNPEP |
| Gene ID | 506882 |
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | kidney, lung, and immune cells; expressed in many organ systems with especially high activity in the brain and testis |
| Protein Function | play an essential role in cellular metabolism that has remained conserved throughout evolution; regulation of the renin-angiotensin system |
| Biochemical Properties | acidic residue specific aminopeptidases; belongs to the M18 metallopeptidase family; is a self-compartmentalized, binuclear zinc-containing enzyme that forms a tetrahedron-shaped homododecameric complex; cytosolic, although it also exists in a membrane-associated form in some tissues; inhibitors - Nonselective metal chelators, reducing agents, and a substrate analog, aspartic acid hydroxamate |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| CATH | Matched CATH superfamily 3.40.630.10 2.30.250.10 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 3VAR, 3VAT, |
| Bibliography | 1. Chen, Y. et al. (2014) ‘Identification and Characterization of Novel Inhibitors of Mammalian Aspartyl Aminopeptidase’, Molecular Pharmacology, 86(2), pp. 231–242. doi: 10.1124/mol.114.093070. |