Primary Information |
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| BoMiProt ID | Bomi271 |
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| Protein Name | Dihydropteridine reductase |
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| Organism | Bos taurus |
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| Uniprot ID | Q3T0Z7 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001069960.1 |
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| Aminoacid Length | 242 |
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| Molecular Weight | 25504 |
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| FASTA Sequence |
Download |
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| Gene Name | QDPR |
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| Gene ID | 618084 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | several mammalian
sources that include sheep brain and beef adrenal
medulla, the liver of sheep , beef .
rat , monkey and human , and
also from various murine and human cell samples |
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| Protein Function | play vital roles
in the synthesis of the catecholamines dopamine, epinephrine and serotonin and indirectly can also
influence the generation of the melanin pigments; |
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| Biochemical Properties | enzyme is somewhat hydrophobic; as obtained from sheep liver, enzyme exists
as a dimer ; With tetrahydrobiopterin as the source of the quinonoid-dihydropterin
substrate, the Km, for DPNH is about one-fifteenth that
of TPNH, and the Vmax with DPNH is more than three times as
great as it is with TPNH; |
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| Significance in milk | L-phenylalanine catabolism |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1. Connor, E. E. et al. (2008) ‘Effects of increased milking frequency on gene expression in the bovine mammary gland’, BMC Genomics, 9(1), p. 362. doi: 10.1186/1471-2164-9-362.
2. Craine, J. E., Hall, E. S. and Kaufman, S. (1972) ‘The isolation and characterization of dihydropteridine reductase from sheep liver.’, The Journal of biological chemistry, 247(19), pp. 6082–91. Available at: http://www.ncbi.nlm.nih.gov/pubmed/4405600 (Accessed: 4 October 2019). |
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