Search by BoMiProt ID - Bomi271

Primary Information

BoMiProt ID Bomi271
Protein Name Dihydropteridine reductase
Organism Bos taurus
Uniprot IDQ3T0Z7
Milk FractionExosome
Ref Sequence ID NP_001069960.1
Aminoacid Length 242
Molecular Weight 25504
FASTA Sequence Download
Gene Name QDPR
Gene ID 618084
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells several mammalian sources that include sheep brain and beef adrenal medulla, the liver of sheep , beef . rat , monkey and human , and also from various murine and human cell samples
Protein Function play vital roles in the synthesis of the catecholamines dopamine, epinephrine and serotonin and indirectly can also influence the generation of the melanin pigments;
Biochemical Properties enzyme is somewhat hydrophobic; as obtained from sheep liver, enzyme exists as a dimer ; With tetrahydrobiopterin as the source of the quinonoid-dihydropterin substrate, the Km, for DPNH is about one-fifteenth that of TPNH, and the Vmax with DPNH is more than three times as great as it is with TPNH;
Significance in milk L-phenylalanine catabolism
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Connor, E. E. et al. (2008) ‘Effects of increased milking frequency on gene expression in the bovine mammary gland’, BMC Genomics, 9(1), p. 362. doi: 10.1186/1471-2164-9-362.
2. Craine, J. E., Hall, E. S. and Kaufman, S. (1972) ‘The isolation and characterization of dihydropteridine reductase from sheep liver.’, The Journal of biological chemistry, 247(19), pp. 6082–91. Available at: (Accessed: 4 October 2019).