Search by BoMiProt ID - Bomi270

Primary Information

BoMiProt ID Bomi270
Protein Name Beta Defensin 10
Organism Bos taurus
Uniprot IDP46168
Milk FractionMFGM
Ref Sequence ID NP_001108556.1
Aminoacid Length 62
Molecular Weight 6928
FASTA Sequence Download
Gene Name DEFB10
Gene ID 100141457
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function amphipathic cationic peptides that have been reported to function as AMPs for the Gramnegative, Gram-positive bacteria, viruses, fungi, and other unicellular parasites; confer resistance against mastitis in cattle and buffalo next to the TLRs;
Biochemical Properties cationic and cysteine-rich AMP displaying a varied pattern of cysteine spacing and disulfide bonding between cysteine residues;
Significance in milk higher in early lactation stages than in the later stages on infection by coagulase-positive Staphylococci
PTMs Disulfide bond formation and Pyrrolidone carboxylic acid attachment
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 54-58,61-62
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Birchler, T. et al. (2001) ‘Human Toll-like receptor 2 mediates induction of the antimicrobial peptide human beta-defensin 2 in response to bacterial lipoprotein.’, European journal of immunology, 31(11), pp. 3131–7. doi: 10.1002/1521-4141(200111)31:11<3131::AID-IMMU3131gt;3.0.CO;2-G.