Primary Information |
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| BoMiProt ID | Bomi2681 |
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| Protein Name | Renin receptor |
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| Organism | Bos taurus |
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| Uniprot ID | P81134 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001091491.1 |
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| Aminoacid Length | 351 |
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| Molecular Weight | 39491 |
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| FASTA Sequence |
Download |
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| Gene Name | ATP6AP2 |
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| Gene ID | 513520 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | The PRR is essential for lysosomal functions, such as endocytosis, secretion, and autophagy as well as for cell division and differentiation, embryonic development, organogenesis, and stem cell biology. |
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| Biochemical Properties | This protein consists of 350 amino acids and has a molecular size of about 37–39 kD, a long N-terminal extracellular domain with a typical signal peptide for the translational transport to the endoplasmic reticulum, a single transmembrane domain, and a short intracellular domain. |
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| PTMs | Cleavage on pair of basic residues, Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (310-332) |
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| Significance of PTMs | Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments. |
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| Bibliography | 1.Peters J. The (pro)renin receptor and its interaction partners. Pflugers Arch. 2017 Oct;469(10):1245-1256. doi: 10.1007/s00424-017-2005-z. Epub 2017 Jun 15. PMID: 28620832. |
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