Search by BoMiProt ID - Bomi2681

Primary Information

BoMiProt ID Bomi2681
Protein Name Renin receptor
Organism Bos taurus
Uniprot IDP81134
Milk FractionWhey
Ref Sequence ID NP_001091491.1
Aminoacid Length 351
Molecular Weight 39491
FASTA Sequence Download
Gene Name ATP6AP2
Gene ID 513520
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function The PRR is essential for lysosomal functions, such as endocytosis, secretion, and autophagy as well as for cell division and differentiation, embryonic development, organogenesis, and stem cell biology.
Biochemical Properties This protein consists of 350 amino acids and has a molecular size of about 37–39 kD, a long N-terminal extracellular domain with a typical signal peptide for the translational transport to the endoplasmic reticulum, a single transmembrane domain, and a short intracellular domain.
PTMs Cleavage on pair of basic residues, Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (310-332)
Significance of PTMs Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments.
Bibliography 1.Peters J. The (pro)renin receptor and its interaction partners. Pflugers Arch. 2017 Oct;469(10):1245-1256. doi: 10.1007/s00424-017-2005-z. Epub 2017 Jun 15. PMID: 28620832.