Search by BoMiProt ID - Bomi261

Primary Information

BoMiProt ID Bomi261
Protein Name Cytochrome b5
Organism Bos taurus
Uniprot IDP00171
Milk FractionExosome
Ref Sequence ID NP_776458.1
Aminoacid Length 134
Molecular Weight 15329
FASTA Sequence Download
Gene Name CYB5A
Gene ID 281110
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function reduce hemoglobin in red blood cells; in non-erythrocyte cells cytosolic cytochrome b5 is required for the reduction of a non-heme, iron-containing cytosolic protein; has role in lipid biosynthesis
Biochemical Properties heme-containing protein; electron transfer protein with a redox potential of 20 mV which is capable of accepting and transferring a single electron; composed of two domains: a hydrophobic tail which anchors the protein to the membrane, and a hydrophilic portion, the heme-binding domain, which is active in redox reactions
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : Alpha and beta proteins (a+b)
Fold : Cytochrome b5-like
Superfamily : Cytochrome b5-like heme/steroid binding domain
Family : Cytochrome b5
Domain Name : 1CYO A:1-88

CATH Matched CATH superfamily
Predicted Disorder Regions 1-6,45-70,88-103
DisProt Annotation
TM Helix Prediction 1TMH ; (109-131)
PDB ID 1CYO, 1EHB, 1ES1, 1F03, 1F04, 1HKO, 1I5U, 1J0Q, 1LQX, 1LR6, 1M20, 1M2I, 1M2M, 1M59, 1NX7, 1SH4, 1U9M, 1U9U, 3OZZ, 4HIN,
Bibliography 1. Bart, A. G. and Scott, E. E. (2017) ‘Structural and functional effects of cytochrome b 5 interactions with human cytochrome P450 enzymes’, Journal of Biological Chemistry, 292(51), pp. 20818–20833. doi: 10.1074/jbc.RA117.000220.