Primary Information |
|---|
| BoMiProt ID | Bomi256 |
|---|
| Protein Name | Carnitine O-palmitoyltransferase 2, mitochondrial |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | Q2KJB7 |
|---|
| Milk Fraction | Exosome |
|---|
| Ref Sequence ID | NP_001039354.1 |
|---|
| Aminoacid Length | 658 |
|---|
| Molecular Weight | 74483 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | CPT2 |
|---|
| Gene ID | 504502 |
|---|
| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
|---|
Secondary Information |
|---|
| Presence in other biological fluids/tissue/cells | located on both sides of the mitochondrial inner
membrane, |
|---|
| Protein Function | catalyse the reversible transfer of a long-chain fatty-acyl group from acyl-CoA to L-carnitine; facilitate the uptake of long-chain fatty acids into the mitochondrial matrix
for oxidation. CPT2(carnitine palmitoyltransferase 2) and CACT(carnitine/acylcarnitine translocase) are crucial for mitochondrial acylcarnitine formation and export to the extracellular fluids in mFAOD. |
|---|
| Biochemical Properties | CPT-A (in outer membrane) is more
easily removed from rat liver mitochondria by digitonin
extraction; CPT-A is strongly
inhibited by malonyl-CoA, CPT-B is less sensitive to
malonyl-CoA; As found in bovine liver mitochondria, The pl is low (pH 6.0); Km for carnitine increases below pH 7.0; |
|---|
| Significance in milk | control lipid metabolism and helps in synthesis of medium chain fatty acids in mammary gland |
|---|
| PTMs | N6-acetylation at Lysine |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| |
|---|
| Predicted Disorder Regions | NA |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Bibliography | 1. Ramsay, R. R. et al. (1987) ‘Purification and properties of the soluble carnitine palmitoyltransferase from bovine liver mitochondria.’, The Biochemical journal, 244(2), pp. 271–8. doi: 10.1042/bj2440271. 2.Violante S, Ijlst L, Te Brinke H, Tavares de Almeida I, Wanders RJ, Ventura FV, Houten SM. Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines. FASEB J. 2013 May;27(5):2039-44. doi: 10.1096/fj.12-216689. Epub 2013 Jan 15. PMID: 23322164. |
|---|
