Search by BoMiProt ID - Bomi255

Primary Information

BoMiProt ID Bomi255
Protein Name Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Organism Bos taurus
Uniprot IDP00423
Milk FractionMFGM
Ref Sequence ID NP_001001439.1
Aminoacid Length 169
Molecular Weight 19572
FASTA Sequence Download
Gene Name COX4I1
Gene ID 281090
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function terminal enzyme of the respiratory chains of mitochondria; use the electrons of cytochrome c to reduce molecular oxygen; central role in aerobic metabolism- participates in respiratory control
Biochemical Properties members of the superfamily of heme/copper containing terminal oxidases;
PTMs phoshorylated
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All alpha proteins
Fold : Single transmembrane helix
Superfamily : Mitochondrial cytochrome c oxidase subunit IV
Family : Mitochondrial cytochrome c oxidase subunit IV
Domain Name : 1V54 D:4-147

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (102-120)
Significance of PTMs activity can be modulated according to the energetic requirement of the cell through isoform subunits composition and physiologically controlled phosphorylation
PDB ID 1OCC, 1OCO, 1OCR, 1OCZ, 1V54, 1V55, 2DYR, 2DYS, 2EIJ, 2EIK, 2EIL, 2EIM, 2EIN, 2OCC, 2Y69, 2YBB, 2ZXW, 3ABK, 3ABL, 3ABM, 3AG1, 3AG2, 3AG3, 3AG4, 3ASN, 3ASO, 3WG7, 3X2Q, 5B1A, 5B1B, 5GPN, 5IY5, 5LUF, 5W97, 5WAU, 5X19, 5X1B, 5X1F, 5XDQ, 5XDX, 5XTH, 5XTI, 5Z84, 5Z85, 5Z86, 5ZCO, 5ZCP, 5ZCQ, 6NKN, 6NMF, 6NMP, 7COH, 7CP5, 7D5W, 7D5X,7EV7,
Bibliography 1. Zong, S. et al. (2018) ‘Structure of the intact 14-subunit human cytochrome c oxidase.’, Cell research, 28(10), pp. 1026–1034. doi: 10.1038/s41422-018-0071-1.
2. Tsukihara, T. et al. (1996) ‘The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 A’, Science, 272(5265), pp. 1136–1144. doi: 10.1126/science.272.5265.1136.
3. Linder, D., Freund, R. and Kadenbach, B. (1995) ‘Species-specific expression of cytochrome c oxidase isozymes’, Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 112(3), pp. 461–469. doi: 10.1016/0305-0491(95)00093-3.