Primary Information |
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| BoMiProt ID | Bomi2509 |
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| Protein Name | Profilin-1 |
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| Organism | Bos taurus |
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| Uniprot ID | P02584 |
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| Milk Fraction | Whey, MFGM, Exosome |
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| Ref Sequence ID | NP_001015592.1 |
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| Aminoacid Length | 140 |
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| Molecular Weight | 15057 |
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| FASTA Sequence |
Download |
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| Gene Name | PFN1 |
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| Gene ID | 513895 |
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| Protein Existence Status | Reveiwed:Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | Profilin 1 (PFN1) is a ubiquitous small-molecule protein that exists in all eukaryotes. PFN1 plays a vital role in many cell functions, including membrane trafficking, endocytosis, cell cycle, motility, proliferation, cell survival, transcription, stemness, and autophagy. |
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| Biochemical Properties | PFN1 is recognized to have 3 domains: an actin-binding domain, a poly-L-proline (PLP)-binding domain, and a phosphoinositide-binding domain. |
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| PTMs | N-Acetylation at Ala, Isopeptide bond formation, Phosphorylation at Ser, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation. |
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| Additional Comments | Abnormal expression or deletion of PFN1 can affect the normal physiological activity of cells and lead to disease development. |
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| Bibliography | Wang Y, Wang Y, Wan R, Hu C, Lu Y. Profilin 1 Protein and Its Implications for Cancers. Oncology (Williston Park). 2021 Jul 15;35(7):402-409. doi: 10.46883/ONC.2021.3507.0402. PMID: 34264570. |
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