Search by BoMiProt ID - Bomi2509

Primary Information

BoMiProt ID Bomi2509
Protein Name Profilin-1
Organism Bos taurus
Uniprot IDP02584
Milk FractionWhey, MFGM, Exosome
Ref Sequence ID NP_001015592.1
Aminoacid Length 140
Molecular Weight 15057
FASTA Sequence Download
Gene Name PFN1
Gene ID 513895
Protein Existence Status Reveiwed:Experimental evidence at protein level

Secondary Information

Protein Function Profilin 1 (PFN1) is a ubiquitous small-molecule protein that exists in all eukaryotes. PFN1 plays a vital role in many cell functions, including membrane trafficking, endocytosis, cell cycle, motility, proliferation, cell survival, transcription, stemness, and autophagy.
Biochemical Properties PFN1 is recognized to have 3 domains: an actin-binding domain, a poly-L-proline (PLP)-binding domain, and a phosphoinositide-binding domain.
PTMs N-Acetylation at Ala, Isopeptide bond formation, Phosphorylation at Ser, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.
Additional Comments Abnormal expression or deletion of PFN1 can affect the normal physiological activity of cells and lead to disease development. 
Bibliography Wang Y, Wang Y, Wan R, Hu C, Lu Y. Profilin 1 Protein and Its Implications for Cancers. Oncology (Williston Park). 2021 Jul 15;35(7):402-409. doi: 10.46883/ONC.2021.3507.0402. PMID: 34264570.