Search by BoMiProt ID - Bomi2500

Primary Information

BoMiProt ID Bomi2500
Protein Name Low molecular weight phosphotyrosine protein phosphatase
Organism Bos taurus
Uniprot IDP11064
Milk FractionExosome
Ref Sequence ID NP_776403.1
Aminoacid Length 158
Molecular Weight 18055
FASTA Sequence Download
Gene Name ACP1
Gene ID 280977
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function Protein tyrosine phosphatase acts as a positive regulator of tumor progression.
PTMs Phosphorylation at Tyr,N-acetylation at Ala,Disulfide bond formation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs LMWPTP has two cysteines at the catalytic site (Cys12 and Cys17). Due to this peculiar feature, unique among the PTP family, LMWPTP can form S–S intramolecular bonds that protect the catalytic Cys12 from irreversible oxidation.
PDB ID 1BVH, 1C0E, 1DG9, 1PHR, 1PNT, 1Z12, 1Z13, 5JNV, 5JNW,
Bibliography 1.Faria AVS, Fonseca EMB, Cordeiro HG, Clerici SP, Ferreira-Halder CV. Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks. Cell Mol Life Sci. 2021 Feb;78(4):1263-1273. doi: 10.1007/s00018-020-03657-x. Epub 2020 Oct 14. PMID: 33052434. 2.Chiarugi P (2001) The redox regulation of LMW-PTP during cell proliferation or growth inhibition. IUBMB Life 52(1–2):55–59. 3.He R, Wang J, Yu ZH, Zhang RY, Liu S, Wu L, Zhang ZY (2016) Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. J Med Chem 59(19):9094–9106.