Primary Information |
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| BoMiProt ID | Bomi2500 |
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| Protein Name | Low molecular weight phosphotyrosine protein phosphatase |
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| Organism | Bos taurus |
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| Uniprot ID | P11064 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_776403.1 |
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| Aminoacid Length | 158 |
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| Molecular Weight | 18055 |
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| FASTA Sequence |
Download |
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| Gene Name | ACP1 |
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| Gene ID | 280977 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | Protein tyrosine phosphatase acts as a positive regulator of tumor progression. |
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| PTMs | Phosphorylation at Tyr,N-acetylation at Ala,Disulfide bond formation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | LMWPTP has two cysteines at the catalytic site (Cys12 and Cys17). Due to this peculiar feature, unique among the PTP family, LMWPTP can form S–S intramolecular bonds that protect the catalytic Cys12 from irreversible oxidation. |
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| PDB ID | 1BVH, 1C0E, 1DG9, 1PHR, 1PNT, 1Z12, 1Z13, 5JNV, 5JNW, |
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| Bibliography | 1.Faria AVS, Fonseca EMB, Cordeiro HG, Clerici SP, Ferreira-Halder CV. Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks. Cell Mol Life Sci. 2021 Feb;78(4):1263-1273. doi: 10.1007/s00018-020-03657-x. Epub 2020 Oct 14. PMID: 33052434. 2.Chiarugi P (2001) The redox regulation of LMW-PTP during cell proliferation or growth inhibition. IUBMB Life 52(1–2):55–59. https://doi.org/10.1080/15216540252774775. 3.He R, Wang J, Yu ZH, Zhang RY, Liu S, Wu L, Zhang ZY (2016) Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. J Med Chem 59(19):9094–9106. https://doi.org/10.1021/acs.jmedchem.6b00993. |
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