Search by BoMiProt ID - Bomi2471

Primary Information

BoMiProt ID Bomi2471
Protein Name Phosphatidylethanolamine-binding protein 1
Organism Bos taurus
Uniprot IDP13696
Milk FractionWhey, Exosome
Ref Sequence ID NP_001028795.1
Aminoacid Length 187
Molecular Weight 20986
FASTA Sequence Download
Gene Name PEBP1
Gene ID 431786
Protein Existence Status Reveiwed;Experimental evidence at protein level

Secondary Information

Protein Function  Phosphatidylethanolamine-binding protein 1 (PEBP1) has the ability to suppress the Raf1-mitogen activated protein kinase pathway, and therefore is also named Raf1 kinase inhibitory protein.PEBP1 also promotes oligodendrocyte and neuronal differentiation.
PTMs Disulfide bond formation, Phosphorylation at Ser/thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-50,134-141,185-187
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 1A44, 1B7A,
Additional Comments Overexpression of PEBP1 or administering PEP-1-PEBP1 ameliorates ischemia-induced neuronal damage in brain ischemia models.
Bibliography 1.Kim W, Cho SB, Jung HY, Yoo DY, Oh JK, Choi GM, Cho TG, Kim DW, Hwang IK, Choi SY, Moon SM. Phosphatidylethanolamine-Binding Protein 1 Ameliorates Ischemia-Induced Inflammation and Neuronal Damage in the Rabbit Spinal Cord. Cells. 2019 Oct 31;8(11):1370. doi: 10.3390/cells8111370. PMID: 31683736; PMCID: PMC6912576. 2.Purification and structural analysis of hippocampal cholinergic neurostimulating peptide. Ojika K, Kojima S, Ueki Y, Fukushima N, Hayashi K, Yamamoto M.Brain Res. 1992 Feb 14; 572(1-2):164-71. 3.Raf kinase inhibitor protein enhances neuronal differentiation in human SH-SY5Y cells.Hellmann J, Rommelspacher H, Mühlbauer E, Wernicke C.Dev Neurosci. 2010 Mar; 32(1):33-46. 4.Directed neural lineage differentiation of adult hippocampal progenitor cells via modulation of hippocampal cholinergic neurostimulating peptide precursor expression.Sagisaka T, Matsukawa N, Toyoda T, Uematsu N, Kanamori T, Wake H, Borlongan CV, Ojika K.Brain Res. 2010 Apr 23; 1327():107-17.