Primary Information | |
---|---|
BoMiProt ID | Bomi2471 |
Protein Name | Phosphatidylethanolamine-binding protein 1 |
Organism | Bos taurus |
Uniprot ID | P13696 |
Milk Fraction | Whey, Exosome |
Ref Sequence ID | NP_001028795.1 |
Aminoacid Length | 187 |
Molecular Weight | 20986 |
FASTA Sequence | Download |
Gene Name | PEBP1 |
Gene ID | 431786 |
Protein Existence Status | Reveiwed;Experimental evidence at protein level |
Secondary Information | |
Protein Function | Phosphatidylethanolamine-binding protein 1 (PEBP1) has the ability to suppress the Raf1-mitogen activated protein kinase pathway, and therefore is also named Raf1 kinase inhibitory protein.PEBP1 also promotes oligodendrocyte and neuronal differentiation. |
PTMs | Disulfide bond formation, Phosphorylation at Ser/thr |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
Predicted Disorder Regions | 1-50,134-141,185-187 |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
PDB ID | 1A44, 1B7A, |
Additional Comments | Overexpression of PEBP1 or administering PEP-1-PEBP1 ameliorates ischemia-induced neuronal damage in brain ischemia models. |
Bibliography | 1.Kim W, Cho SB, Jung HY, Yoo DY, Oh JK, Choi GM, Cho TG, Kim DW, Hwang IK, Choi SY, Moon SM. Phosphatidylethanolamine-Binding Protein 1 Ameliorates Ischemia-Induced Inflammation and Neuronal Damage in the Rabbit Spinal Cord. Cells. 2019 Oct 31;8(11):1370. doi: 10.3390/cells8111370. PMID: 31683736; PMCID: PMC6912576. 2.Purification and structural analysis of hippocampal cholinergic neurostimulating peptide. Ojika K, Kojima S, Ueki Y, Fukushima N, Hayashi K, Yamamoto M.Brain Res. 1992 Feb 14; 572(1-2):164-71. 3.Raf kinase inhibitor protein enhances neuronal differentiation in human SH-SY5Y cells.Hellmann J, Rommelspacher H, Mühlbauer E, Wernicke C.Dev Neurosci. 2010 Mar; 32(1):33-46. 4.Directed neural lineage differentiation of adult hippocampal progenitor cells via modulation of hippocampal cholinergic neurostimulating peptide precursor expression.Sagisaka T, Matsukawa N, Toyoda T, Uematsu N, Kanamori T, Wake H, Borlongan CV, Ojika K.Brain Res. 2010 Apr 23; 1327():107-17. |