Primary Information
BoMiProt ID	Bomi242
Protein Name	Cytosolic carboxypeptidase 3
Organism	Bos taurus
Uniprot ID	E1B9D8
Milk Fraction	Whey
Aminoacid Length	1003
Molecular Weight	116561
FASTA Sequence	Download
Gene Name	AGBL3
Protein Existence Status	Reviewed: Protein inferred from homology
Secondary Information
Protein Function	Some carboxyl peptidase (CPs) function in the degradation of proteins in the digestive tract while other enzymes play biosynthetic roles in the formation of neuropeptides and peptide hormones; CPs modify tubulin by removing amino acids from the Cterminus and from polyglutamyl side chains, thereby altering the properties of microtubules;
Significance in milk	active in human milk throughout lactation; digests milk within mammary gland
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	1-23, 642-662, 911-1003
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1. Wu, H.-Y. et al. (2015) ‘Comparison of the enzymatic and functional properties of three cytosolic carboxypeptidase family members.’, The Journal of biological chemistry, 290(2), pp. 1222–32. doi: 10.1074/jbc.M114.604850. 2. Dallas, D. C. et al. (2013) ‘Extensive in vivo Human Milk Peptidomics Reveals Specific Proteolysis Yielding Protective Antimicrobial Peptides’, Journal of Proteome Research, 12(5), pp. 2295–2304. doi: 10.1021/pr400212z. 3. Khaldi, N. et al. (2014) ‘Predicting the Important Enzymes in Human Breast Milk Digestion’, Journal of Agricultural and Food Chemistry, 62(29), pp. 7225–7232. doi: 10.1021/jf405601e.