Search by BoMiProt ID - Bomi242

Primary Information

BoMiProt ID Bomi242
Protein Name Cytosolic carboxypeptidase 3
Organism Bos taurus
Uniprot IDE1B9D8
Milk FractionWhey
Aminoacid Length 1003
Molecular Weight 116561
FASTA Sequence Download
Gene Name AGBL3
Protein Existence Status Reviewed: Protein inferred from homology

Secondary Information

Protein Function Some carboxyl peptidase (CPs) function in the degradation of proteins in the digestive tract while other enzymes play biosynthetic roles in the formation of neuropeptides and peptide hormones; CPs modify tubulin by removing amino acids from the Cterminus and from polyglutamyl side chains, thereby altering the properties of microtubules;
Significance in milk active in human milk throughout lactation; digests milk within mammary gland
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-23, 642-662, 911-1003
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Wu, H.-Y. et al. (2015) ‘Comparison of the enzymatic and functional properties of three cytosolic carboxypeptidase family members.’, The Journal of biological chemistry, 290(2), pp. 1222–32. doi: 10.1074/jbc.M114.604850.
2. Dallas, D. C. et al. (2013) ‘Extensive in vivo Human Milk Peptidomics Reveals Specific Proteolysis Yielding Protective Antimicrobial Peptides’, Journal of Proteome Research, 12(5), pp. 2295–2304. doi: 10.1021/pr400212z.
3. Khaldi, N. et al. (2014) ‘Predicting the Important Enzymes in Human Breast Milk Digestion’, Journal of Agricultural and Food Chemistry, 62(29), pp. 7225–7232. doi: 10.1021/jf405601e.