Primary Information | |
---|---|
BoMiProt ID | Bomi2416 |
Protein Name | Cation-independent mannose-6-phosphate receptor |
Organism | Bos taurus |
Uniprot ID | P08169 |
Milk Fraction | Whey, MFGM, Exosome |
Ref Sequence ID | NP_776777.1 |
Aminoacid Length | 2499 |
Molecular Weight | 274529 |
FASTA Sequence | Download |
Gene Name | IGF2R |
Gene ID | 281849 |
Protein Existence Status | Reveiwed:Experimental evidence at protein level |
Secondary Information | |
Biochemical Properties | Functionally, the receptor binds IGF-II and M6P-containing ligands at distinct sites: repeat 11 comprises the core IGF-II binding site, whereas repeats 3, 5, 9, and 15 bind substrates with M6P groups. |
PTMs | N6-acetylation at Lysine,Phosphorylation at Serine,S-palmitoylation,Omega-N-methylation at Arginine |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
Predicted Disorder Regions | NA |
DisProt Annotation | |
TM Helix Prediction | 1TMH; (2314-2336) |
Significance of PTMs | Undergoes cysteine S-palmitoylation which promotes interaction with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus. |
PDB ID | 1Q25, 1SYO, 1SZ0, 2KVA, 2KVB, 6UM1, 6UM2, |
Additional Comments | The cation-independent mannose 6-phosphate receptor (CI-MPR) is responsible for the trafficking of mannose 6-phosphate-tagged proteins to lysosomes via Golgi sorting and from extracellular locations through endocytosis. |
Bibliography | 1.Baldwin AC, Naatz A, Bohnsack RN, Bartosiak JT, Oleson BJ, Hansen PA, Dahms NM, Corbett JA. Cation-Independent Mannose 6-Phosphate Receptor Deficiency Enhances β-Cell Susceptibility to Palmitate. Mol Cell Biol. 2018 Mar 29;38(8):e00680-17. doi: 10.1128/MCB.00680-17. PMID: 29378831; PMCID: PMC5879465. 2.Brown J, Esnouf RM, Jones MA et al (2002) Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur. EMBO J 21(5):1054–1062. 3.Wang, Y.; MacDonald, R.G.; Thinakaran, G.; Kar, S. (2017). Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases. Molecular Neurobiology, 54(4), 2636–2658. doi:10.1007/s12035-016-9849-7 |