Search by BoMiProt ID - Bomi2416

Primary Information

BoMiProt ID Bomi2416
Protein Name Cation-independent mannose-6-phosphate receptor
Organism Bos taurus
Uniprot IDP08169
Milk FractionWhey, MFGM, Exosome
Ref Sequence ID NP_776777.1
Aminoacid Length 2499
Molecular Weight 274529
FASTA Sequence Download
Gene Name IGF2R
Gene ID 281849
Protein Existence Status Reveiwed:Experimental evidence at protein level

Secondary Information

Biochemical Properties Functionally, the receptor binds IGF-II and M6P-containing ligands at distinct sites: repeat 11 comprises the core IGF-II binding site, whereas repeats 3, 5, 9, and 15 bind substrates with M6P groups.
PTMs N6-acetylation at Lysine,Phosphorylation at Serine,S-palmitoylation,Omega-N-methylation at Arginine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (2314-2336)
Significance of PTMs Undergoes cysteine S-palmitoylation which promotes interaction with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus.
PDB ID 1Q25, 1SYO, 1SZ0, 2KVA, 2KVB, 6UM1, 6UM2,
Additional Comments The cation-independent mannose 6-phosphate receptor (CI-MPR) is responsible for the trafficking of mannose 6-phosphate-tagged proteins to lysosomes via Golgi sorting and from extracellular locations through endocytosis.
Bibliography 1.Baldwin AC, Naatz A, Bohnsack RN, Bartosiak JT, Oleson BJ, Hansen PA, Dahms NM, Corbett JA. Cation-Independent Mannose 6-Phosphate Receptor Deficiency Enhances β-Cell Susceptibility to Palmitate. Mol Cell Biol. 2018 Mar 29;38(8):e00680-17. doi: 10.1128/MCB.00680-17. PMID: 29378831; PMCID: PMC5879465. 2.Brown J, Esnouf RM, Jones MA et al (2002) Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur. EMBO J 21(5):1054–1062. 3.Wang, Y.; MacDonald, R.G.; Thinakaran, G.; Kar, S. (2017). Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases. Molecular Neurobiology, 54(4), 2636–2658. doi:10.1007/s12035-016-9849-7