Search by BoMiProt ID - Bomi2300

Primary Information

BoMiProt ID Bomi2300
Protein Name Glutathione peroxidase 1
Organism Bos taurus
Uniprot IDP00435
Milk FractionExosome
Ref Sequence ID NP_776501.1
Aminoacid Length 205
Molecular Weight 22659
FASTA Sequence Download
Gene Name GPX1
Gene ID 281209
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects.
Biochemical Properties The selenoenzyme glutathione peroxidase(GSH-Px) is a tetramer of identical subunits each exhibiting a molecular weight of 21kDa.
PTMs Glycation at Lys-110,Phosphorylation at Serine,N6-acetylation at Lys
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs The effects of glycation decides the hydrogen bond distances between carbonyl oxygen and nitrogen atoms of hydrogen bonded pairs in the active site helix of glutathione peroxidase.In the presence of water, there are significant increases in the hydrogen bond distances of Thi-48, Val-49, Tyr-52 and Thr-53, as a result of glycation of glutathione peroxidase by molecular modelling.
Bibliography 1.Lubos E, Loscalzo J, Handy DE. Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2011 Oct 1;15(7):1957-97. doi: 10.1089/ars.2010.3586. Epub 2011 Apr 10. PMID: 21087145; PMCID: PMC3159114. 2.Baldwin JS, Lee L, Leung TK, Muruganandam A, Mutus B. Identification of the site of non-enzymatic glycation of glutathione peroxidase: rationalization of the glycation-related catalytic alterations on the basis of three-dimensional protein structure. Biochim Biophys Acta. 1995 Feb 22;1247(1):60-4. doi: 10.1016/0167-4838(94)00202-r. PMID: 7873592.