Primary Information |
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| BoMiProt ID | Bomi2292 |
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| Protein Name | Guanine nucleotide-binding protein G(i) subunit alpha-1 |
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| Organism | Bos taurus |
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| Uniprot ID | P63097 |
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| Milk Fraction | MFGM, Exosome |
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| Ref Sequence ID | NP_776749.1 |
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| Aminoacid Length | 354 |
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| Molecular Weight | 40361 |
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| FASTA Sequence |
Download |
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| Gene Name | GNAI1 |
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| Gene ID | 281790 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | The alpha subunits of the stimulatory and inhibitory G proteins, Gs alpha and Gi alpha, activate transmembrane-signaling systems involved in the control of cell proliferation. |
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| Biochemical Properties | A much higher degree of amino acid sequence homology is observed between the alpha-subunits of Gi and transducin (68%) than between those of Gi and the adenylate cyclase-stimulating G-protein (Gs) (43%) or between those of transducin and Gs (42%). |
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| PTMs | Myristoylation at Gly-2,Palmitoylation at Cys-3 |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | 5-32,203-214,343-354 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Myristoylation at Gly-2 takes place for membrane anchoring before palmitoylation. |
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| PDB ID | 6K42, 6NBF, 6NBH, 6NBI, 7D68, |
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| Additional Comments | The constitutive expression of Gi alpha-1 in autonomous adenoma may allow for the unregulated stimulation of thyroid cell proliferation. |
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| Bibliography | 1.Nukada T, Tanabe T, Takahashi H, Noda M, Haga K, Haga T, Ichiyama A, Kanagawa K, Hiranaga M, Matsuo, et al. Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence. FEBS Lett. 1986 Mar 3;197(1-2):305-10. doi: 10.1016/0014-5793(86)80347-7. PMID: 2419165. 2.Selzer E, Wilfing A, Schiferer A, Hermann M, Grubeck-Loebenstein B, Freissmuth M. Stimulation of human thyroid growth via the inhibitory guanine nucleotide binding (G) protein Gi: constitutive expression of the G-protein alpha subunit Gi alpha-1 in autonomous adenoma. Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1609-13. doi: 10.1073/pnas.90.4.1609. PMID: 8434024; PMCID: PMC45924. |
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