Search by BoMiProt ID - Bomi2277

Primary Information

BoMiProt ID Bomi2277
Protein Name Rho GDP-dissociation inhibitor 1
Organism Bos taurus
Uniprot IDP19803
Milk FractionWhey, MFGM, Exosome
Ref Sequence ID NP_788823.1
Aminoacid Length 204
Molecular Weight 23421
FASTA Sequence Download
Gene ID 338054
Protein Existence Status Reveiwed:Experimental evidence at protein level

Secondary Information

Protein Function RhoGDIα may induce myofibroblast transdifferentiation and thus result in silicosis.
Biochemical Properties RhoGDIα can interact with small GTPases and prevent them switching from their inactive GDP-bound state to an active GTP-bound state.
PTMs N6-acetylation at Lysine, Isopeptide bond formation, Phosphorylation at Ser, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions (1-47)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Wei Z, Xu H, Zhang Y, Yi X, Yang X, Chen Y, Mao N, Li S, Xu D, Li S, Zhang H, Li D, Zhang G, Zhang B, Jin F, Gao X, Cai W, Zhang L, Wang R, Yang F. Rho GDP dissociation inhibitor α silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling. Exp Cell Res. 2019 Jul 15;380(2):131-140. doi: 10.1016/j.yexcr.2019.04.026. Epub 2019 Apr 25. PMID: 31029634.